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Act early, live longer
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Act early, live longer

Comprehensive preventive care in a world class clinic
Personalized early warning systems for disease risk
Long-term guidance with exceptional care
Move better with Hyperice
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Move better with Hyperice

Normatec compression boots help increase circulation
Hypervolt massage guns help improve range of motion
Venom heat and massage wraps help loosen soreness
Unlock Your Health Potential
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Unlock Your Health Potential

Swiss-Made, Science-Backed Supplements
Rejuvenate with Clean, High-Quality Nutrition
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Science based longevity solutions
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Science based longevity solutions

Cutting edge supplement formulations - made in Germany
Developed by medical doctors - with third-party lab tests
Proteomic testing platform for lifestyle and age assessment
Germany’s leading B2B & B2C longevity event
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Germany’s leading B2B & B2C longevity event

100+ speakers, 4 stages, 20 workshops, 12 experiences
Performance, biotech, beauty and wellness in one place
Meet world renowned experts, exchange ideas and grow together
Sleep better, perform stronger
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Sleep better, perform stronger

Suitable for allergy sufferers & hypoallergenic
90 nights free sleep trial
Suitable for at home and on the go

Discover health stacks

Martin Brüggemann

Hannover, Germany

Partner, Dad, Co-Founder t3n, CTO (20+ years), Espresso-Lover, Ultracycling enthusiast and Longevity Fan. CTO New Zapiens GmbH.

Callum Parker

San Francisco, CA, USA 26 years

Biohacker, exercise enthusiast, KALOS. https://www.livekalos.com/ First person to hit 1000lb club and 4:30 mile same day. My favourite supplement is creatine.

Floris Roltsch

Boltenhagen, Germany 33 years

Data Scientist • Co-founder LONGEVITAL • I want to maintain optimal health and performance until 60 years old and stay free from chronic disease until 90 or longer. • Built LONGEVITAL to help me and others get there by combining biomarkers & BioAge with daily feedback through effortless lifestyle tracking.

Sandra

Munich, Germany 39 years

I believe in primary prevention as a mean to counter-balance individual genetic risks. Super interested in functional medicine, but frustrated about the limited options available in Germany (anyone around in Munich? ;-) ). Medical Doctor and Molecular Biologist by training (but not providing medical services myself anymore)

Hadi Saleh

Berlin, Germany

Trained Orthopedic Surgeon Entrepreneur - CEO of CeramTec Group, a midcap German „Hidden Champion“ Since more than 9 years I have embarked on the journey to find out how I can optimize my life towards a healthy long life - striving to live to 120 years. I have a German Podcast called „Mission Gesundheit“ dealing with all topics regarding to health and have written a book with the same title.

Heiko Bartlog

Berlin, Germany 50 years

Mentor for Vitality with special expertise in Essential Micronutrients: Measure – Plan – Optimize – repeat! With years of experience as a Project Management Consultant, Coach for Leadership and Agility, Facilitator for Co-Creation and Effectuation Expert.

Guillaume Agis

Toulouse, France 35 years

CTO @ Ikare.ai , Tech entrepreneur & biohacker

Simon Krüger

Berlin, Germany 41 years

Love the water in summer and the mountains in winter. Father of 3. Entrepreneur. Co-founder Doctolib Germany and New Zapiens 🚀

Mario Gietl

Munich, Germany 27 years

Medical doctor & Co-Founder of the german longevity company MOLEQLAR®. Interested in a science-backed approach to healthy aging and longevity involving nutrition, supplements and health tech.

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MOLEQLAR - Health and wellness company

MOLEQLAR

4.7
• 34 Reviews

MOLEQLAR offers a range of high-quality supplements and lab tests designed to enhance longevity, performance, and overall well-being. Their products include a proprietary proteomic testing platform as well as NMN, resveratrol, spermidine, and other essential compounds aimed at supporting cellular health.

YEARS - Health and wellness company

YEARS

5.0
• 1 Review

YEARS offers the Personal Aging Check, providing the most comprehensive knowledge about your body you have ever experienced.

BLACKROLL - Health and wellness company

BLACKROLL

4.5
• 31 Reviews

BLACKROL offers a wide range of foam rollers and fascia training tools designed to improve mobility, performance, and recovery.

Nurosym - Health and wellness company

Nurosym

4.2
• 5 Reviews

Nurosym offers a wearable device designed to provide relief from various conditions, such as Long-COVID, PTSD, depression, and more. The device uses non-invasive neuromodulation to stimulate the vagus nerve, helping to improve overall well-being.

Polar - Health and wellness company

Polar

4.4
• 10 Reviews

Polar is a global leader in heart rate monitors, fitness trackers, and sports watches. Their products are designed to help athletes and fitness enthusiasts track their performance and achieve their fitness goals.

Eight Sleep - Health and wellness company

Eight Sleep

4.5
• 4 Reviews

Eight Sleep offers the intelligent sleep system designed to improve sleep quality through advanced technology. Their products include smart mattresses and accessories that provide personalized sleep tracking and temperature regulation.

Sunday Natural - Health and wellness company

Sunday Natural

4.6
• 120 Reviews

Sunday offers natural vitamins, supplements, and vital substances to support overall health and well-being.

Hyperice - Health and wellness company

Hyperice

4.8
• 5 Reviews

Hyperice provides innovative technology to enhance muscle recovery and improve mobility.

Aware - Health and wellness company

Aware

4.5
• 19 Reviews

Aware offers an app that provides deep insights into your health by tracking vitamin D, glucose, and cholesterol levels. Their technology helps users monitor and improve their overall well-being with real-time data and personalized recommendations.

Oura - Health and wellness company

Oura

4.2
• 23 Reviews

Oura Ring is a smart ring designed to track sleep, activity, and overall health. It provides insights into sleep quality, readiness, and daily activity levels, helping users make informed decisions about their health and well-being.

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Founder interview: Moritz Fürste, co-founder and CEO of HYROX
Endurance Training

12 min read

Founder interview: Moritz Fürste, co-founder and CEO of HYROX

In our Founder Interview series, we showcase the brightest minds in preventive health, wellness, and longevity. In episode 2, we introduce Moritz Fürste, Co-Founder of the indoor fitness race HYROX.Tell us a little about yourself and your current ventureI am Moritz Fürste, one of the co-founders of HYROX. In my first life, I was a hockey player; I played for the German national team for a long time and participated in three Olympic Games. That was my first life, as I sometimes say. I had a long and intense career in competitive sports and was able to gain many valuable experiences, both athletically and personally. Sport has always shaped me, but after my active career, the question arose: What now? In 2017, we founded HYROX, and since then, it has been my focus. We wanted to offer people who regularly go to the gym a new challenge – a kind of sporting goal that goes beyond mere training. Our vision is to establish Fitness Racing as a global sport vertical. A lot has happened in recent years, and more and more people are getting excited about this sport.  How do you manage to balance your business and your personal health as a founder and entrepreneur?Yes, I believe that largely depends on the job. For me, extrinsic motivation plays a big role. Through my profession, I am surrounded every day by movement, fitness, and people who train. That motivates me tremendously! In our team, we often train together – whether it’s swimming during the lunch break or a short gym session after work. I notice that this social input helps to keep me going.I am naturally more of a ball sport athlete, so I would normally prefer to arrange to play tennis or golf rather than go to the gym. But the incentive to participate in a HYROX event and improve my personal best drives me. It gives me a concrete reason to train. I am essentially my own guinea pig and can experience firsthand how much a clear goal increases motivation. Because nothing is more motivating than knowing: In a few weeks, there is an event – and if I don’t train, it will be quite a torment.Do you do HYROX yourself, or do you combine it with strength training, CrossFit, or a mix of different training methods?I mix a lot: cardio, strength training, and interval training. My training is strongly oriented towards HYROX, but of course, I am not a professional HYROX athlete. The sport is a very balanced mix of strength and endurance, which is why my training is broad-based. Any training that is structured holistically is basically a good HYROX training session. I try to incorporate specific elements from our competition, but also to remain variable to continually challenge the body in new ways.This means for me concretely: I do a combination of classic strength training, functional exercises, and intense endurance sessions. I work a lot with intervals, as that is one of the main components of HYROX. A training session can, for example, look like this: First, I run a few kilometers at an easy pace, then follow some strength training sets – and finally, a crisp interval training session. This mix is ideal because it builds both strength and endurance.And what is your personal health goal?Simply to stay as fit as possible! As you get older, that becomes more challenging, and you have to put in more effort to maintain the same standard. My goal is to preserve my fitness level for as long as possible so that I can continue doing everything that I enjoy. I don’t want to have to limit myself and want to be able to participate in competitions for as long as possible.But I also notice that as you age, not only physical fitness but also mental fitness plays an increasingly important role. That’s why I try to lead a balanced lifestyle – with sufficient sleep, good nutrition, and of course, regular training.In addition, I believe that social interaction is an important component of health. Sport can be done in isolation, but in a community or with training partners, it is not only more fun but also helps you stay motivated in the long run.Is there a fitness myth you would like to debunk? Yes, a typical myth is that more training automatically brings better results. Many people overdo it and neglect regeneration. The body needs time to adapt and become stronger. Anyone who trains seven days a week without scheduling any recovery time will, in the long run, harm themselves rather than benefit. Quality over quantity is the key here!  You interact daily with people who participate in HYROX competitions, prepare for them, or are generally active in the fitness and health sector. What are some of the most exciting things you have learned from the community? Are there any particular stories or insights that have surprised you?That is a very good question because we are indeed constantly learning, both on a structural and individual level. What personally impresses me the most is the range of participants. On one hand, we have absolute elite athletes who consider HYROX an extension of their professional training. On the other hand, there are people who have only discovered sport through HYROX. This diversity is incredibly inspiring.A particularly impressive example is our oldest participant, an 83-year-old who started in the doubles format together with his daughter. He has proven that it is never too late to face new challenges. His attitude has inspired many other older people to also try HYROX.Another important lesson is the significance of inclusion in sport. There are many people who feel excluded in traditional fitness environments, whether due to a lack of sporting background, social barriers, or insecurities. HYROX has managed to create a community where everyone feels welcome. Many participants tell us that they used to go to the gym for years, but only through HYROX did they have a real goal in sight and therefore train with much more motivation.Were there any specific pieces of feedback from the community that led you to further develop or adjust HYROX? Absolutely. One of the most important insights was that many participants regard the training as just as important as the competition itself. That led us to integrate HYROX classes into more and more gyms worldwide. It’s not enough just to offer events; people need a structured way to prepare, to become familiar with the format, and to see progress.Another point was the demand for different performance levels. We realized that there cannot be just one elite or beginner category. That’s why we introduced different categories, including doubles and relay formats, which allow beginners to enter the sport. This has significantly lowered the barrier for newcomers.  What trends or technologies do you see as potential game-changers in the coming years, whether for HYROX or for the fitness industry in general?I think the greatest potential lies in data integration and personalization. Today, many people track their workouts with smartwatches, but the possibilities go far beyond that. I envision that in the future we will see many more personalized training recommendations based on real-time data. For example, a platform could analyze how you perform in a HYROX event and then tell you exactly which training adjustments you should make to compensate for your weaknesses.Another exciting area is artificial intelligence in training. There are already systems that give you real-time feedback on your running technique or strength training. This will continue to develop and ensure that people can train even more efficiently without necessarily having a personal trainer on-site. Is there another fitness myth that you would like to completely dispel? Yes, namely the myth that more is always better. Many people think that they have to train hard every day to make progress. But recovery is just as important as the training itself! Without sufficient regeneration, the body cannot make progress. Quality always comes before quantity.A second myth is that HYROX is only for super fit athletes. That simply isn’t true! Our event format is designed so that everyone can participate, regardless of their fitness level. The only opponent is yourself and your own time from the last event.  Can you give us an insight into your daily routine?Yes, of course, gladly. I am, of course, very branded when it comes to my fitness routine, but at the same time, I try to keep everything as structured and efficient as possible. If I am not injured or sick, I have a fairly standardized routine. I get up at 6:30 in the morning with the kids and walk them to school. Most of the time, they ride their bikes while I accompany them on foot. Depending on how I feel that day, I then run between 5 and 10 kilometers. If it’s too cold or the weather is extremely bad, sometimes I even take the car. Afterwards, I go directly to the gym, which, luckily, is nearby.Are you more of a morning person when it comes to sport?Yes, definitely. My routine is to train between 8 and 9 in the morning. I track my metrics with Amazfit, our partner. It can essentially do everything that other fitness trackers can. The topic of sleep especially interests me a lot. Since I started tracking my sleep, I have been much more focused on getting enough sleep. I almost see it as a challenge: I want my sleep score to be good. And if there’s an opportunity to optimize it, then I certainly try to do so.Besides the gym and running – are there any other sports that you regularly engage in?Yes, once a week I play tennis. Otherwise, I try to incorporate other sporting activities whenever the opportunity arises. But my main focus is definitely on my running and strength training routine. Apart from that, I spend a lot of time in the office and on weekends I am usually somewhere on a sports field.Do you regularly get health check-ups, or do you wait until something is wrong? Yes, absolutely! I just had a comprehensive blood test done this week. After reviewing the results, I took high-dose magnesium and two or three other vitamins because I was at the very low end. It’s all done as a preventive measure; I don’t do it very regularly – I would say I take the time for it every two years. Of course, it would be ideal to do it more frequently, but that is currently hard to implement. Especially during the winter months, my vitamin supply is an important topic. Magnesium is particularly crucial for me because I have a high demand, especially in combination with intensive training sessions.What about dietary supplements? Is there anything that you supplement on a permanent basis?Yes, but I keep it relatively simple. I regularly supplement with Vitamin D and Magnesium, nothing else. My wife is a naturopath and osteopath, so we do a lot in the area of gut health and prevention. She guides that a bit for me. We also work with probiotics and prebiotics to keep the gut flora stable.Do you view it critically that many people try to optimize their health to an extreme?Yes, I believe that many people overdo it. They take 50 different supplements and try to optimize every little detail. But ultimately, it is the basics that really count: sufficient sleep, healthy nutrition, regular exercise, and a good balance in life. About 80 to 90 percent of health comes from these fundamentals. The rest may be relevant for some, but for most, it is not necessary.Which books or podcasts have particularly inspired you on your journey?I have spent a long and intensive time with the books of Yuval Noah Harari. Homo Deus and Sapiens particularly impressed me. In addition, I found Factfulness by Hans Rosling very exciting because it offers a more optimistic view of the world. I am generally a fan of not only focusing on the negative but also highlighting the positive. Unfortunately, in our society, only the negative is often discussed, even though there are many advances.How do you see the difference between the positive feedback in sports and the often critical feedback in the professional world?I study the science of positivity – if you can even call it that. I often criticize the constant emphasis on everything that isn’t going well without also focusing on the positive things. We paint such a distorted picture that it seems as though the world is constantly on the brink of disaster. Yet, if you zoom out, you could actually conclude that the world has never been better. This perspective is particularly important to me – whether in sports or in entrepreneurship.In sports, you constantly receive feedback in all directions. When you are a child and score a goal, your entire team gets excited, hugs you – even if it is sometimes not phrased very nicely, you still feel the positive feedback. In the professional world, it is different: Here, praise is rarely given. Instead, there is often criticism, even when you have done something right. I believe that companies and leaders could learn a lot from the way successes are celebrated in sports. That would not only boost motivation but also foster a more positive corporate culture.

Why light therapy should be on your radar – the biology speaks for itself
Light Therapy

5 min read

Why light therapy should be on your radar – the biology speaks for itself

Sunlight is the foundation of all life on Earth, providing the energy that has shaped our planet from the very start. It is only in recent times that scientists are beginning to understand the profound impact light has on the human body and mind. The sun emits so much energy and provides life for the planet and humans to thrive off of. It’s a critical fuel source for all species and flora. Without the sun’s light, all life on Earth would cease to exist.In school, we learn that plants absorb light energy from the sun through chlorophyll and photon receptors in the leaves and then transform it into chemical energy. This process is called photosynthesis. Why is it so abstract to think that our human bodies can convert sunlight into different forms of energy?Well, here’s the reality, our bodies do just that every single day they are exposed to sunlight. Like plants, humans have photon receptors in our cells that enable light energy to be absorbed and start chain reactions that result in energy production. When sunlight penetrates our skin, skull, and brain tissue, our cell’s mitochondria react by increasing ATP production, which is the fuel our bodies and brains need to function.Throughout human history, civilizations across the globe have used sunlight to prevent or alleviate some diseases. Ancient Egyptians worshipped the sun. In some countries, hospital beds were moved outside so patients to heal from disease in the sun. Later on, we had the advent of LEDs and lasers and NASA even used light therapy first to grow plants at the International Space Station to then later discover it could also help with acceleration of wound healing when dealing with injured astronauts.The sunlight is not only beneficial, but without it, you may experience mood changes and can lead to depression. According to Healthline, “Decreased sun exposure has been associated with a drop in your serotonin levels, which can lead to major depression with seasonal patterns.” In addition, “Due to this connection, one of the main treatments for depression with seasonal pattern is light therapy, also known as phototherapy.”Light therapy is becoming an integral part of the modern doctor’s toolbox for a vast array of applications such as neurodegeneration, and neuropsychiatric conditions, but the question most New Zapiens readers will want to know is, how can light therapy be used in my life? What are the applications and benefits?Increase in cognitive processing speedLight therapy may not give you superhuman intelligence and cognition, however, small increases in your cognitive processing speed are possible. At a 2024 Super Bowl event In Las Vegas, a college athlete used a Neurocatch Assessment tool using brain event-related potentials or ERPs to measure his processing speed baseline. After recording the baseline he used Neuronic’s light therapy helmet (Neuradiant 1070 nm) for just one 6-minute session and then did a follow-up measurement with the Neurocatch device. He found a staggering 14% increase in his cognitive processing speed.Boost in short-term memory by up to 25%In a 2022 study conducted by the University of Birmingham published study, individuals used a near-infrared laser on their prefrontal cortex. The hypothesis is that since the prefrontal cortex is associated with short-term memory performance, applying light there would encourage energy production and enhance the function of this region of the brain. The study found that individuals experienced an increase in their short-term memory by up to 25%.Enhancing sleep and detoxificationSleep is an essential aspect and fundamental to our health. While we sleep, the body undergoes lymphatic drainage, a process that removes toxins and waste, including glymphatic drainage in the brain, which helps clean and repair tissues overnight. A recent study shows that light therapy can accelerate this process. The authors of the paper suggest that “photobiomodulation helps improve the overall quality of sleep, and hence well-being and long-term health, of many individuals.”Reducing brain fog and improving focusSince the COVID-19 pandemic, we’ve become well-versed with the effects of brain fog, including the potentiality to experience long-term, life-altering symptoms. In April 2023 a study reported using light therapy to alleviate symptoms associated with brain fog. Subjects mentioned that before the therapy they were experiencing high levels of fatigue, had a hard focusing, and lacked the mental acuity to function well with a clear head throughout the day. After using the light therapy devices (either a full light therapy bed or a light helmet 3 times a week) for a month, users reported significant benefits and the cognitive tests supported their subjective statements.Light therapy, also known as photobiomodulation, harnesses the biological power of light to support essential physiological processes, providing the body and mind with the energy they need to thrive. We’ve explored how natural sunlight fuels life, the consequences of insufficient exposure, and how advancements in light-based technologies now allow us to bring these benefits into our daily lives.From enhancing cognitive function and memory to improving sleep, detoxification, and mental clarity, light therapy is emerging as a non-invasive, research-backed approach to optimizing health, performance, and well-being. With increasing scientific support and real-world applications, it’s becoming an essential tool in modern wellness.

Measuring what matters? The challenges of quantifying the living self…
Quantified Self

10 min read

Measuring what matters? The challenges of quantifying the living self…

Biohacking – seriously? WHAT? You don’t collect the biodata of your entire organism around the clock? And you don’t have 30+ doctors to constantly monitor your well-being and carry out sophisticated tests? And – even worse – you’re not pondering new quantifiable longevity interventions all day long?How *can* you be a serious biohacker?!?OK, so let’s face it, we can’t all be Bryan Johnson (and we may not want to). Nevertheless, serious biohacking relies on meaningful and accurate measurement modalities. Indeed, what’s the point of “punishing” health routines or “risky” interventions if there’s no tangible added value?So, as a mere (im)mortal, with a day job, friends, maybe a family, and other hobbies beyond longevity, you are faced with a quandary. The quandary of what to measure, how (much) to measure, how frequently and, last but not least, how to correctly interpret the data obtained – i.e., on your own, with professional help and/or with AI. Lost in the data forestBecause that’s the dizzying part, isn’t it? The data challenge… There are now myriad bio-/performance markers you can access and choose from. You can collect your data actively or passively. You can focus on DIY or professional data, or both. Indeed, not only can you rely on traditional medical check-ups, but you can also self-surveil with wearables and all manner of other appliances. Furthermore, you can access a cornucopia of sophisticated consumer health tests – covering anything from proteomics to microbiome composition, through food allergies. So, while it makes sense to track basic health parameters as well as personal issues and areas you want to improve, you may be left with a nagging uncertainty and wonder, “Am I really getting the bigger picture here? What could I be missing?”.Hmm, the essence of the body as a *living* being, maybe?Beyond the flesh machineBecause this is where the metaphor of “body as machine” breaks down, since the body is so much more than the sum of its parts. Indeed, we are all aware that: perfect heart health + perfect gut health + perfect (you name it) does not necessarily = perfect health (or increased longevity). What a bummer… So, that’s the ultimate biotechnological challenge, isn’t it? Adequately capturing the body as a living organism with self-developing, self-organising, self-regulating and self-repairing capacities. But also, as an organism highly dependent on the inputs of its environment(s) over time to maintain balance or “homeostasis”, as it is called in medical jargon.  What can we then do until science understands and manages to model the most intimate workings of our individual bodies with all their idiosyncrasies? Will there ever be a convincing model with which we can assess ourselves and confidently affirm, “I am perfectly healthy, and chances are I will live to be a healthy 100!”? Well, AI or AGI may eventually help us to obtain a web of interlocking factors that (appear to) signify and/or promote human health, hence longevity. The software of lifeMeanwhile, however, a promising strategy to get the bigger picture of our health and longevity lies in the field of epigenetics since epigenetics is especially attuned to the individual, living and evolving dimensions of our bodies. But what is epigenetics?Put simply (but mechanistically: sorry!), epigenetics is the field that studies the biochemical “software” around your genome that activates or silences your DNA “hardware”. The most common “switch” examined is so-called methylation that occurs at specific sites of the genome called CpGs. So, you inherit your DNA hardware from your parents as both fact (e.g., the colour of your eyes) and potential (e.g., the propensity towards certain health conditions). And there’s not much you can do about it, since it has evolved very slowly over generations. But the good news is that this inheritance only has a limited influence on your health and longevity outcomes. Current estimates are between 10 to 20%.Hence, you need not be blighted with “bad” genes!   Indeed, the epigenetic software, which we partially inherit but which is mostly steered by our environment, is dynamic. And since you have at least some control over what surrounds you, you can actively (or passively) influence your health, hence your longevity.More concretely: the way you live your life, i.e. eat, move, sleep, manage your stress, etc. has a massive impact on your healthspan. From epigenetics to biological ageing“Yeah, yeah, OK, but that’s not really new, is it? Even my Gran could have told you that… What about the hard stuff? The biohacking and the measuring?”Well, that’s where it gets really interesting. In the past decade – starting with Hannum’s and Horvath’s first groundbreaking epigenetic clocks – epigeneticists have been developing biochemical tests or so-called “clocks” to precisely measure the overall ageing of the body.You’ve surely noticed this discrepancy: some people celebrating their 70th birthday look ready for the nursing home, while others are planning to solo-climb the Kilimanjaro. How come?This is because the body does not necessarily age linearly. So, it may or may not be in synch with the candles on your birthday cake. For instance, if you’re confronted with a major stressor – say, you unexpectedly lose your job or your partner dies – chances are that this traumatic event will take a toll on your health, hence your longevity. So, your biological ageing can suddenly (and brutally) accelerate. It may even visibly show up as “overnight” white hair or a sallow, wrinkled complexion. But in uneventful or more harmonious times, ageing can increase very slowly, or even plateau as well as potentially decrease. Hence, the aim of an epigenetic clock is to capture a still or snapshot within the film of your ageing. The biological age determined by the clock enables you to compare it with your chronological age and see whether you are ageing more rapidly or slowly than your age cohort.Biological age: a super-marker?So, for biohackers, what are the advantages of tracking biological age compared to other markers?To tackle this “philosophical” question, you need to look back at the evolution of epigenetic clocks. Originally, epigenetic clocks were strictly meant for experimental settings and were extremely expensive and unwieldy to run. Even more crucially, biological age estimates were not very precise and were difficult to replicate. This could be due to any number of factors: the types of tissues or fluids from which DNA was extracted, the identity and/or number of genomic regions (CpGs) analysed and their correlations with ageing, the architecture of the algorithms, small or inadequate training cohorts as well as technical noise. All these issues made them unsuitable for the average consumer. Nowadays, however, with 3rd and soon 4th generation clocks, many of these issues have been overcome and the tests have become much more user-friendly and affordable. There are of course different analytical methodologies championed within the epigenetic scene. Many companies still bet on so-called chip-arrays that promise extensive coverage of a large number of CpGs but lead to, e.g., problems with replication, due to technical noise and other issues. Other companies have already switched to so-called NGS (or Next Generation Sequencing). This new technology involves fewer CpGs but more in-depth analysis, making for better replication and significant cost-cutting, among other aspects.    Most significantly, however, researchers are now able to zone in on the CpGs that most convincingly correlate with ageing. And that is the major advantage of biological age as a marker. Epigenetic testing usually takes a meta-approach to measuring ageing, rather than concentrating on the ages of particular fluids, tissues, organs or metabolic systems in the body (though some clocks also target the micro-level). So, instead of looking for direct causal links to ageing, the epigenetic focus is on an overall correlation with ageing.  Why does this approach make sense? It makes sense because ageing is an extremely complex process we are only beginning to unravel. A process involving a myriad changes on both micro- and macro-levels of the body, as described by the “hallmarks of ageing” model. Hence, depending on your health history, it may certainly make sense to specifically monitor your blood sugar or your microbiome. But it is also crucial to obtain a more comprehensive picture of your health and ageing – a picture that captures ageing at a systemic level.  And, currently, biological age determination is the best strategy to do just that. Current limitations and future promisesBecause epigenetic testing is still in its infancy as a technology, a lot remains to be done. There are already many peer-reviewed studies focusing on the impact of disease and stress on biological ageing, but there are still few studies on the effects of positive lifestyle changes. This has to do with the well-known challenge of financing experiments based on lifestyle modifications rather than drug-based interventions. But another difficulty arises from designing studies that enable the isolation of a particular lifestyle factor for investigation. Indeed, because their focus is usually systemic, current epigenetic tests are not attuned to singling out specific aspects of lifestyle such as nutritional habits or sleep patterns. So, as a biohacker, if you wish to monitor the effects of your new sports routine using epigenetic testing, you will have to ensure that you do not change other variables in your lifestyle at the same time (such as e.g., supplementation). And beyond the realm of what you may be able to control, there are other “random” factors that can muddy the waters. For instance, some illnesses – especially highly infectious ones such as Covid-19 or the flu – as well as pronounced inflammatory states can initially accelerate biological ageing. Upon recovery, however, biological age typically returns to the baseline.Moreover, stress (be it sudden and/or chronic) also appears to have deleterious effects. Here again, though, biological age can normalise over time if stress is alleviated.From an empirical and, as yet, very anecdotal perspective, some interesting patterns are emerging, as reported by individuals frequently testing themselves and physicians testing their patients on a regular basis:Some positive lifestyle changes may be rapidly reflected in biological age, others may take longer.Radical positive changes may initially cause age acceleration because the body initially perceives them as stress. This tends to reverse over time. Synergistic changes, such as concurrently improving nutrition, sleep and movement while mitigating stress, seem to pay the highest and fastest dividends.Nevertheless, biology remains very individual: the same habits, routines, and supplements tend to have different effects on different people. Obviously, these tentative findings will have to be confirmed by peer-reviewed studies. But they open fascinating vistas for dedicated biohackers who are intent on quantifying their individual, living and evolving selves! 

How NAD supplements may support healthy aging — and how MOLEQLAR fits in
Sponsored
NAD+

10 min read

How NAD supplements may support healthy aging — and how MOLEQLAR fits in

Have you ever wondered why some people maintain high energy levels, mental clarity, and overall vitality as they get older? For many years, scientists have been investigating that question by looking into nicotinamide adenine dinucleotide, commonly abbreviated as NAD+ or simply NAD. This tiny coenzyme seems to play a big role in healthy aging—supporting everything from DNA repair to energy production—and it has become one of the most researched molecules in longevity science.Below, we’ll explore what NAD is, why its levels naturally decline with age, and how the brand MOLEQLAR offers a multifaceted approach with its regeNAD (NAD Regenerating Complex). While NAD+ might be a central piece of the longevity puzzle, remember that no single supplement is a magic bullet. The goal is to better understand the science behind NAD+ so you can make informed decisions about your health and wellness journey.NAD+ 101: The basicsWhat exactly is NAD?NAD stands for nicotinamide adenine dinucleotide, a molecule composed of two mononucleotides linked together via a chemical bond. You’ll find NAD in almost all of your cells, acting somewhat like a co-pilot (a “coenzyme”) to hundreds of different enzymes. Without NAD’s electron-carrying capabilities, many metabolic processes in the body would slow down or halt altogether.NAD+ vs. NADHNAD+ is the oxidized form of the molecule, ready to pick up electrons.  NADH is the reduced form, loaded with electrons to donate.  In your mitochondria—often called the “power plants” of the cell—NADH hands off electrons to the electron transport chain, thereby facilitating the production of ATP (adenosine triphosphate). This ATP powers nearly every cellular activity you undertake, from muscle movement to nerve signals.Why the buzz about NAD levels?NAD levels appear to decline with age, which some researchers believe could be a major driver of metabolic sluggishness, decreased cellular repair, and increased susceptibility to age-related disorders. In various animal models, boosting NAD+ leads to improved insulin sensitivity, cognitive function, and even lifespan extension. Early human studies have shown similarly promising, though not yet conclusive, results. This has fueled a surge of interest in ways to maintain or increase NAD+ levels through diet, lifestyle changes, or targeted supplementation.A brief historical perspectiveEarly discoveries1906: Scientists Arthur Harden and William Young first described NAD in the context of alcoholic fermentation. Interestingly, NAD is involved in both alcohol production (during fermentation) and its breakdown in the body.  1930s: Otto Warburg demonstrated NAD’s significance in redox reactions, which are electron-exchange processes fundamental to energy production in cells and to various industrial applications (like pyrotechnics and margarine manufacturing).From DNA repair to “Longevity Genes”1960s: Researchers discovered NAD’s involvement in DNA repair, specifically with enzymes known as PARPs (poly(ADP-ribose) polymerases).  Modern Focus—Sirtuins: NAD’s popularity today largely stems from its role in activating a family of enzymes called sirtuins (SIRT1–7). Sirtuins are sometimes referred to as “longevity genes” because they influence cellular metabolism, stress responses, and genetic stability. When NAD+ levels are high, sirtuins function more optimally.Niacin: The first cholesterol-lowering “Medication”Long before statins and PCSK9 inhibitors, high-dose niacin (a precursor of NAD) was used in the 1950s to reduce LDL cholesterol levels. This historical tidbit underscores the complexity of vitamin B3-related compounds and their importance to human health—even before scientists fully grasped NAD’s extensive role.Why NAD+ declines with ageIt’s well established that NAD+ levels drop significantly over time, but researchers propose several converging factors:Reduced Production: Key enzymes and precursors for NAD+ synthesis, such as NAMPT and certain forms of vitamin B3, may become less abundant as we age.  Increased Breakdown: Enzymes like CD38 and overactive PARPs can speed up NAD degradation. Chronic low-grade inflammation (“inflammaging”) can further elevate CD38 levels.  DNA Damage and Cell Stress: Accumulated DNA damage triggers more frequent use of NAD in repair processes, depleting available supplies.Potential benefits of higher NAD+Scientists have studied NAD’s role in many tissues, often focusing on how supporting NAD+ might promote “healthspan”—the years of life lived in good health rather than just lifespan.Brain and Cognitive Function: NAD+ is critical for mitochondrial performance within neurons. Some studies suggest improving NAD+ levels may support memory, reduce age-related cognitive decline, and even offer mild protection against noise-induced hearing loss.  Muscle Performance: Muscle cells require ample ATP, which depends on robust mitochondrial function—and thus NAD+. Animal models repeatedly show enhanced muscular endurance and strength when NAD+ is supported through supplementation or genetic manipulation.Heart Health: The heart’s endurance is unmatched—beating more than a billion times in an average lifespan. High concentrations of mitochondria (and the NAD+ they rely on) help maintain the consistent contractions. Early findings indicate that boosting NAD+ in older animals can improve cardiac function and resilience.Liver and Detoxification: The liver handles energy storage, protein synthesis, and detoxification. All these processes depend on enzyme systems that require NAD. It follows that higher NAD+ may support more efficient detox pathways.Immunity and Viral Defense: During certain viral infections, NAD helps fuel specific subsets of PARP enzymes that bolster cellular immunity. Researchers investigating SARS-CoV-2 noted that higher NAD+ levels might support antiviral responses—though the evidence is preliminary and may not generalize to all viral infections.‘Longevity Genes’ and the Hallmarks of Aging: Sirtuins, often called “longevity genes,” appear to rely on NAD+ to modulate multiple hallmarks of aging, including DNA repair, inflammatory pathways, and stress responses. By ensuring adequate NAD, you potentially influence a broad suite of age-related processes.Introduction to MOLEQLAR’s regeNAD (NAD Regenerating Complex)MOLEQLAR, a company dedicated to advanced nutrition and longevity research, has developed regeNAD (NAD Regenerating Complex) to tackle the multifaceted nature of NAD+ metabolism. Rather than depending on a single ingredient, regeNAD supplies various vitamin B3 derivatives—most notably nicotinamide D-ribose, which has garnered attention for its potentially greater efficacy compared to plain nicotinamide (Nam).While nicotinamide and nicotinic acid (niacin) remain valuable for feeding the Salvage and Preiss-Handler pathways, respectively, the inclusion of nicotinamide D-ribose offers a more direct route to key NAD+ intermediates. This shift responds directly to critiques that highlight the need for advanced forms of B3 beyond simple nicotinamide.Additionally, regeNAD includes L-tryptophan to support the De Novo pathway, vitamin B6 to facilitate NMN conversion into NAD+, and apigenin, an ingredient that may help inhibit CD38—a major contributor to NAD+ breakdown. Together, these components aim to optimize multiple steps of NAD+ metabolism, reflecting the growing consensus that targeted approaches like nicotinamide D-ribose can be more effective than relying solely on standard forms of vitamin B3.Spotlight on RiaGev®RiaGev is a proprietary blend of D-ribose and nicotinamide designed to support NAD+ biosynthesis and antioxidant capacity. A 2022 study published in Nutrients found that RiaGev supplementation in overweight or obese adults significantly increased NAD+ and glutathione levels, suggesting enhanced cellular energy metabolism and improved redox balance. These findings point to RiaGev’s potential role in maintaining metabolic health, particularly in individuals seeking targeted approaches to bolster NAD+ status.Don’t Miss Niagen® NR (NR plus TMG)Alongside regeNAD, MOLEQLAR also offers Niagen® NR, available as NR plus TMG Capsules. Niagen® is a branded form of nicotinamide riboside, one of the best-researched vitamin B3 derivatives. Studies have shown that NR can effectively raise NAD+ levels in humans, with potential benefits for metabolic function, cognitive support, and cellular resilience. Coupled with trimethylglycine (TMG), this formulation aims to enhance methylation processes—another factor that influences gene expression and overall metabolic health.Whether you choose regeNAD or Niagen® NR+, MOLEQLAR’s product range underscores the company’s commitment to clinically tested solutions for healthy aging. RiaGev® in regeNAD and Niagen® NR both align with the latest research on how best to maintain robust NAD+ levels. More than supplements: The holistic approachA holistic approach to healthy aging goes beyond simply taking supplements. Regular exercise, for instance, is known to upregulate the enzyme NAMPT, which indirectly helps maintain NAD+ levels. Intermittent fasting or caloric restriction may also support NAD+ by boosting sirtuin activity and reducing inflammation. In addition, a balanced diet that includes vitamin B3-rich foods (such as fish, meat, and whole grains) and amino acids like L-tryptophan can provide the essential building blocks for NAD+ synthesis. Before making any major changes—be it dietary shifts or supplementation—it’s helpful to establish a baseline. To this end, MOLEQLAR has teamed up with the University of Vilnius to develop an at-home NAD test kit. By using a simple dry blood sample, the kit measures your current NAD+ levels, allowing you to track how these levels respond to different interventions and helping you identify the most effective strategies for your individual needs. In addition to regeNAD, MOLEQLAR offers other products, such as the Fasten-Bundle, which includes compounds like Glucosamin, Berberin, and Spermidin to support various molecular aspects of fasting. Although these are not directly related to NAD+ metabolism, they can enhance an overall approach to metabolic health by assisting the body in managing stress responses, insulin sensitivity, and cellular maintenance.Is NAD+ the “Fountain of Youth”?While high NAD+ levels correlate with numerous markers of robust aging, we must remember that no single supplement can replace a healthy lifestyle. The field is still evolving, with plenty of unanswered questions about the interplay between inflammation, CD38 levels, sirtuin activation, and NAD metabolism. Future research may further clarify the best methods, dosages, and timing for NAD+ support.Here’s what we do know:NAD+ is fundamental to processes like cellular energy, DNA repair, and immune defense.  Levels drop with age, and this decline often coincides with reduced metabolic health and resilience.  Boosting NAD+ — by slowing its breakdown, providing enzymatic cofactors, and ensuring adequate precursors — seems to help maintain various aspects of healthspan in animal models and early human trials.  MOLEQLAR’S regeNAD stands out for embracing multiple pathways and steps in NAD synthesis and breakdown. Though no approach guarantees the proverbial “fountain of youth,” a well-rounded regimen that includes a balanced diet, regular exercise, good sleep, and thoughtful supplementation could tip the scales in favor of better aging.Final thoughtsNAD+ is more than just another health buzzword. Decades of biochemical and clinical research underscore its importance in keeping our cells running smoothly — especially as we grow older. Understanding NAD’s history, its complex web of pathways, and the factors that cause its decline allows us to make more nuanced choices about how to support healthy aging.MOLEQLAR recognizes the multi-faceted nature of NAD+ metabolism, which is why it developed regeNAD (NAD Regenerating Complex) to cover many bases—precursor supply, enzyme support, and breakdown inhibition. If you’re curious about how your NAD+ level shapes your daily life, consider measuring it using their at-home NAD test kit, then consult with a healthcare professional to figure out the best approach for your unique situation.Disclaimer: This advertorial is for informational purposes only and does not constitute medical advice. Always speak with a qualified healthcare provider before starting any new supplement, especially if you have underlying health conditions or take other medications. Results may vary, and research on NAD+ continues to evolve.

The 9-hour athlete: top 10 sleep secrets for peak performance
Recovery

3 min read

The 9-hour athlete: top 10 sleep secrets for peak performance

Imagine yourself in a perfect world. Your mood is vibrant and positive. Your brain functions at peak efficiency. Your body feels healthy, energetic, and capable.In this perfect world, you’re not only eating a balanced diet and following an ideal training routine, but you’re also getting enough restorative sleep to unlock your full potential.Restful sleep is absolutely essential for your health, as well as your physiological and psychological recovery and performance.How much sleep should you get, and what happens when you don’t?Adults should aim for 7 to 9 hours of sleep per night to fully recover their body and mind. High-performance athletes are recommended to get at least 9 hours of sleep per night.Sleep should be given the same importance as training and nutrition. Just as you need more calories than the average person, you also need more restorative sleep.Unfortunately, the reality is often different. Many athletes sleep too little or have disturbed sleep. Training and competition demands, along with external stressors, can affect both the need for and quality of sleep. This, in turn, can negatively impact mood and performance.A U.S. study involving 189 college athletes found that:68% reported poor sleep quality87% slept less than or equal to 8 hours per night43% slept fewer than 7 hours per nightThe consequences of sleep deprivation on performance and health include:Impaired sprint ability: A study on male team athletes showed that sleep deprivation reduced both average and total sprint times.Decreased accuracy: Tennis players experienced up to a 53% reduction in serve accuracy after sleep deprivation.Slower reaction times: Sleep deprivation significantly impaired reaction times among male college athletes.Faster exhaustion: Lack of sleep can reduce the time to physical exhaustion by up to 30%.Example: After a poor night’s sleep before a 10,000-meter race, you may hit physical exhaustion as early as 7,000 meters.Impaired learning and decision-making: Sleep deprivation negatively affects executive functions.Examples: It becomes harder to retain learned motor skills from training and recall them during competition. You’re also more likely to make poor decisions, such as rushing a shot instead of passing the ball during play.Increased stress and risk of burnoutHormonal and metabolic disturbances: These can contribute to weight issues.Weakened immune system: This increases your risk of infections, particularly colds and upper respiratory illnesses.Higher injury risk: Chronic sleep deprivation can increase injury risk by up to 70%.Sounds far from ideal, doesn’t it? That’s why your goal should be to get sufficient and high-quality sleep on most nights — for optimal recovery, performance, and long-term health.What if that’s not possible sometimes?Here are some practical, tested tips for achieving restorative sleep: Regular sleep and wake times (max. +/- 30min) throughout the entire week, even on weekends to avoid 'social jet lag'.Cozy, high-quality bed (mattress, pillows, etc.) and a dark “sleep cave”.Avoid intensive mental or physical activities 2-3 hours before sleep.Early, balanced meal for dinner 2-3 hours before sleep.Fresh, circulating air flow and cool room temperature between 16-20°C.Sufficient sunlight exposure throughout the day — ideally right after waking up to support your circadian rhythm.Stop having caffeine (6-10 hours) and alcohol (4-5 hours) before sleep.No electronic devices (at least 1 hour) before going to sleep.Stress reduction/relaxation routine, e.g. meditation, relaxing breathing exercises (4-7-8), stretching, yoga, 'Shakti Mat', reading, journaling, etc.Power napping, no longer than 20 minutes and not later than 6-7h before bedtime to avoid negative impact on night sleep.

DEXA scans: the gold standard for measuring bone density and body composition
Body Composition

6 min read

DEXA scans: the gold standard for measuring bone density and body composition

Okay, let's dive deep into DEXA scans. These aren't just your average X-rays; they're a sophisticated tool that gives us a remarkable look at what's happening inside our bodies, specifically when it comes to bone health and body composition. It's like having a window into our internal landscape, revealing crucial information that can help us live healthier, longer lives.So, what exactly is a DEXA scan? DEXA stands for Dual-Energy X-ray Absorptiometry. It's a non-invasive imaging technique, widely considered the gold standard for measuring bone mineral density (BMD). But it's not just about bones; DEXA scans also provide detailed information about body composition, including fat mass, lean muscle mass, and bone mineral content. Think of it as a two-for-one deal – a comprehensive assessment of both skeletal health and body makeup.A brief history of bone density measurementIt's interesting to consider how we even got to DEXA scans. The journey to accurately measuring bone density has been a long one, actually. Osteoporosis, a condition characterized by weakened bones and increased fracture risk, was recognized as a health issue way back, but figuring out how to quantify bone loss? That was the challenge. Early attempts involved simple X-rays, which could show obvious bone thinning, but weren't very precise. Over time, researchers developed more sophisticated techniques, and finally, DEXA emerged as the clear winner. It's now the go-to method for diagnosing osteoporosis, monitoring treatment effectiveness, and even tracking changes in body composition.How DEXA scans work: The science behind the imageThe science behind DEXA scans is pretty clever. The machine uses two X-ray beams with different energy levels. These beams are directed at the body, and as they pass through different tissues (bone, fat, muscle), they are absorbed at different rates. This difference in absorption allows the DEXA scanner to calculate the density of the bone and the amount of fat and muscle tissue in the scanned area. It's kind of like the machine is "seeing" the different components of your body by how they interact with the X-rays.The procedure itself is quick and painless. You simply lie on a cushioned table, and a scanner arm moves over your body, focusing on key areas like the spine, hip, and forearm – these are common sites for osteoporosis-related fractures. The whole process usually takes between 10 and 20 minutes, and the radiation exposure is minimal, much lower than a standard X-ray.Deciphering the results: T-scores and Z-scoresOnce the scan is complete, you'll receive a report with two key scores: the T-score and the Z-score. Both are important, but they tell slightly different storiesT-score: This is the primary score used to diagnose osteopenia and osteoporosis. It compares your bone density to the average bone density of a healthy young adult (typically someone in their 20s or 30s). A T-score of -1.0 or higher is considered normal. A score between -1.0 and -2.5 indicates osteopenia, meaning you have lower than normal bone density and are at increased risk for osteoporosis. A T-score of -2.5 or lower signifies osteoporosis, a condition characterized by significantly weakened bones and a high risk of fractures.Z-score: This score compares your bone density to the average bone density of people your own age, sex, and ethnicity. It's particularly useful for younger individuals or when trying to identify underlying causes of bone loss. A low Z-score might suggest that something else is going on, like a hormonal imbalance or a nutritional deficiency.Beyond bone density: the body composition advantageOne of the really cool things about DEXA scans is that they also provide a detailed breakdown of your body composition. This includes:Fat mass: The total amount of fat in your body.Lean mass: This includes muscle, bone, and other non-fat tissues.Bone mineral content (BMC): The amount of mineral in your bones.This information can be incredibly valuable for a variety of reasons. For example, if you're trying to lose weight, a DEXA scan can tell you whether you're losing fat or muscle. This allows you to adjust your diet and exercise plan to ensure you're preserving muscle mass while losing fat. Similarly, athletes can use DEXA scans to track their muscle growth and optimize their training programs. And for individuals with certain medical conditions, like sarcopenia (age-related muscle loss), DEXA scans can help monitor muscle mass and guide treatment strategies.The role of DEXA in personalized medicineDEXA scans are playing an increasingly important role in personalized medicine. The detailed information they provide allows healthcare professionals to tailor treatment plans to individual needs. For example, someone with osteopenia might be advised to increase their calcium and vitamin D intake, engage in weight-bearing exercise, and perhaps consider medication to prevent further bone loss. And as we learn more about the link between body composition and health, DEXA scans will likely become even more valuable in preventing and managing a wide range of conditions.Where to get a DEXA scan: finding a reputable facilitySo, you're interested in getting a DEXA scan. Where do you go? Several types of facilities offer DEXA scans, including:Hospitals and medical centers: These are often the most convenient option, as they usually have the latest technology and a team of experienced professionals.Independent imaging centers: These centers specialize in imaging services and may offer more competitive pricing or more flexible scheduling.Community health centers: These centers provide healthcare services to underserved communities and may offer DEXA scans at reduced rates or on a sliding scale.To find a facility near you, you can search online directories, ask your doctor for recommendations, or contact your insurance provider for a list of in-network providers.The future of DEXA technologyThe future of DEXA scans looks bright. Researchers are constantly working to improve the technology and expand its applications. One promising area is the integration of artificial intelligence (AI) and machine learning. These technologies can help analyze DEXA scan data more efficiently and accurately, potentially identifying subtle changes in bone density or body composition that might be missed by the human eye. We may also see DEXA scans being used to assess risk for other conditions, such as cardiovascular disease and diabetes.Another exciting development is the potential for portable DEXA scanners. This would make DEXA scans more accessible to people in remote areas or those with mobility issues. Imagine being able to get a DEXA scan in your doctor's office or even at home!DEXA scans: a valuable tool for health and wellnessIn conclusion, DEXA scans are a valuable tool for assessing bone health and body composition. They provide crucial information that can help us prevent osteoporosis, manage weight, optimize athletic performance, and personalize healthcare. As the technology continues to advance, DEXA scans are poised to play an even greater role in promoting health and wellness for years to come. If you're concerned about your bone health or interested in learning more about your body composition, talk to your doctor about whether a DEXA scan might be right for you.

Latest reviews

- Taste (subjective but awesome aroma) - caffeine extraction via a water process - slow roasting procedure - Abo discount available I have nothing to improve. For some it might be the price but for me the value price is well balanced
Very efficient according to a friend who tested it with 3 different sensors and wanted to buy 1 for each room and for his mother 0 ozone 0 noise (I sleep next to it) 0 filter to change the best in energy consomption quiet expensive at first but less expensive on the long term due to its low energy consomption
Addressing the main targets around NAD+ and Collagen decline, perceivable and visible benefits in first month. -
Super lightweight, great app interface, portable charging via battery pack, great community Definitely have to wash it if you sweat a lot, membership fee is pretty high, you have to open the app to see your stats (no watch interface)
Lightweight tracker, Great app interface, Integrates with other health platforms Battery life doesn't last more than 2-3 days and often dies in the middle of the night
more & more features like stress, VO2max, biological age, heart rate, skin temperature and of course detailed sleep patterns, it's the first thing I check in the morning, sunlight exposure. To have a better sleep score it encourages you to sleep earlier or more I remove it during the day, I wonder about accuracy (because it doesn't actually read your brain waves

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Healthcare is broken

Doctors and pharma companies profit from treating illness, not keeping us healthy.

The wellness industry is full of bold claims with little to no evidence.

Health gurus and influencers capitalize on our insecurities, offering questionable advice that often misleads rather than helps.

In a world where trust is everything, who can we rely on?

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