Magazine | The role of insulin and insulin resistance in longevity

The role of insulin and insulin resistance in longevity

Insulin Sensitivity Inflammation
Written by Ali Boukllouâ 7 min read
The role of insulin and insulin resistance in longevity

Longevity is the ultimate goal for those seeking a longer, healthier, and more fulfilling life. While factors like diet, exercise, and stress management are crucial, the regulation of insulin levels and insulin resistance also play a significant role. But why is this so important, and how can we influence it? This article delves into the scientific foundations of insulin and insulin resistance, explores their impacts on health, and offers practical tips for reducing insulin resistance. 

What are insulin and insulin resistance? 

Insulin is a hormone produced in the pancreas that is essential for regulating blood sugar levels. It helps cells in muscles, fat, and the liver absorb glucose from the blood to use as energy or store as glycogen. Insulin plays a crucial role in carbohydrate, fat, and protein metabolism. 

Insulin resistance occurs when cells in muscles, fat, and the liver do not respond well to insulin, leading to elevated blood sugar levels. This prompts the pancreas to produce more insulin to compensate. Over time, this can result in hyperinsulinemia (excessively high insulin levels) and eventually type 2 diabetes mellitus, heart disease, and other metabolic disorders. 

Scientific foundations and mechanisms 

1. Insulin and glucose homeostasis 

Mechanism: Insulin regulates blood sugar levels by promoting the transport of glucose into cells. In insulin resistance, however, cells respond poorly to insulin, causing glucose to remain in the blood. This leads to chronically elevated blood sugar levels, which can promote inflammation and oxidative stress. 

Study: According to DeFronzo et al. (2009), insulin resistance is not just a precursor to type 2 diabetes mellitus, but also a central factor in the development of cardiometabolic diseases like hypertension and atherosclerosis. 

2. Insulin and fat storage 

Mechanism: Insulin promotes fat storage by inhibiting fat breakdown (lipolysis) and stimulating fat synthesis (lipogenesis). Elevated insulin levels, which are common in insulin resistance, can thus lead to increased fat storage, particularly in the abdominal area. 

Study: A study by Weiss et al. (2016) showed that insulin resistance and hyperinsulinemia are both causes and consequences of obesity, which in turn increases the risk for cardiovascular diseases. 

3. Insulin and cellular aging 

Mechanism: Chronically high insulin levels and insulin resistance can accelerate cellular aging by reducing the activity of telomerase (the enzyme that protects telomeres) and increasing oxidative stress. This can lead to accelerated aging of cells. 

Study: Research by Qin et al. (2016) indicates that insulin resistance and elevated insulin levels promote cellular aging through increased cell damage and age-related degeneration. 

Insulin resistance and chronic diseases 

Insulin resistance is directly related to a variety of chronic diseases that can significantly impair quality of life and lifespan. Here are some of these diseases and their connection to insulin resistance: 

1. Cardiovascular diseases 

Elevated insulin levels and insulin resistance are strong predictors of cardiovascular diseases. Insulin resistance leads to increased production of free radicals, which can damage arterial walls and promote inflammatory processes. 

Study: According to an analysis by Reaven (1988), insulin resistance is the primary cause of metabolic syndrome, a cluster of risk factors for heart disease and stroke.  

2. Type 2 diabetes mellitus 

Persistent high blood sugar levels due to insulin resistance can exhaust the insulin-producing beta cells in the pancreas, ultimately leading to type 2 diabetes mellitus. 

Study: Unger and Orci (2001) explain that insulin resistance plays a key role in the pathophysiology of type 2 diabetes mellitus and can cause long-term complications such as kidney failure and neuropathy. 

3. Obesity 

Elevated insulin levels favor fat storage, leading to obesity and further metabolic disturbances. 

Study: Eckel et al. (2005) demonstrate that insulin resistance is both a cause and a consequence of obesity, creating a vicious cycle that is hard to break.  

4. Neurodegenerative diseases 

Recent research suggests that insulin resistance can also increase the risk for neurodegenerative diseases like Alzheimer’s. 

Study: A study by Craft et al. (2012) shows that insulin resistance and hyperinsulinemia significantly increase the risk for cognitive impairment and Alzheimer’s disease. 

Practical tips for reducing insulin resistance

The good news is that insulin resistance can be reduced through specific lifestyle changes and dietary strategies. Here are some scientifically supported approaches: 

1. Diet 

Low-carb or ketogenic diet: A low-carb diet can help lower insulin levels and improve insulin sensitivity. These diets focus on reducing sugar and starchy foods while emphasizing healthy fats and proteins. 

Study: Hu et al. (2015) found that low-carb diets are effective in controlling blood sugar levels and body weight. 

Fiber-rich foods: Fiber slows the absorption of sugar into the blood and improves insulin sensitivity. Foods such as vegetables, fruits, whole grains, and legumes are high in fiber. 

Study: Weickert and Pfeiffer (2008) demonstrated that fiber improves metabolic health and reduces the risk of insulin resistance. Specific recommendations include carrots, berries, spinach, and oatmeal. 

2. Exercise 

Strength training: Regular strength training helps build muscle mass and increases muscle insulin sensitivity. This leads to better glucose uptake and lower overall blood sugar levels. 

Study: Holten et al. (2004) showed that strength training significantly improves insulin sensitivity in patients with type 2 diabetes mellitus. 

Aerobic exercise: Aerobic activities such as running, cycling, or swimming improve insulin sensitivity and help regulate blood sugar levels. 

Study: Ross et al. (2000) found that regular aerobic exercise improves insulin sensitivity in overweight and obese adults. A 30-minute walk after meals could be a practical recommendation. 

3. Weight Management 

Weight reduction: Even moderate weight loss can significantly improve insulin sensitivity and reduce the risk of type 2 diabetes mellitus. 

Study: Knowler et al. (2002) showed that a weight reduction of just 7% of body weight lowered the risk of developing type 2 diabetes mellitus by 58%. Regular monitoring of BMI and waist circumference can be helpful.  

4. Sleep 

Improved sleep hygiene: Adequate and high-quality sleep supports metabolic health and can help reduce insulin resistance. 

Study: Buxton and Marcelli (2010) found that sleep deprivation significantly impairs insulin sensitivity. Specific tips include securing 7-8 hours of sleep and maintaining consistent sleep schedules. 

5. Stress management 

Stress reduction: Chronic stress can raise insulin levels and lead to insulin resistance. Techniques such as meditation, yoga, and mindfulness can help lower stress levels. 

Study: Black and Slavich (2016) demonstrated that mindfulness practices improve insulin sensitivity and reduce inflammation. 

Additional measures to improve insulin sensitivity 

1. Intermittent fasting 

Intermittent fasting (IF) can be an effective method to improve insulin sensitivity. Various methods include 16:8 (16 hours fasting, 8 hours eating) or 5:2 (5 days normal eating, 2 days calorie restriction). 

Study: Tinsley and La Bounty (2015) found that intermittent fasting can improve insulin sensitivity and lower insulin levels. 

2. Nutritional supplements 

Certain nutritional supplements have been proven to improve insulin sensitivity, including magnesium, omega-3 fatty acids, and berberine. 

  • Magnesium: A study by Guerrero-Romero and Rodriguez-Moran (2011) showed that magnesium improves insulin sensitivity and blood sugar levels. 
  • Omega-3 fatty acids: According to a meta-analysis by Balk et al. (2006), omega-3 fatty acids improve insulin sensitivity and reduce inflammation. 
  • Berberine: A study by Yin et al. (2008) showed that berberine improves insulin sensitivity in patients with type 2 diabetes mellitus. 

3. Hydration 

Adequate hydration is also crucial for maintaining healthy insulin sensitivity. 

Study: A study by Heiss et al. (2017) showed that dehydration can reduce insulin sensitivity. 

Conclusion 

Insulin and insulin resistance play a crucial role in health and longevity. Chronically high insulin levels and insulin resistance can lead to numerous health issues, accelerating aging and diminishing quality of life. Fortunately, there are many proven strategies for improving insulin sensitivity and reducing insulin resistance. A combination of a healthy diet, regular exercise, adequate sleep, and effective stress management can significantly enhance health and promote a long, fulfilling life. 

Published: January 2nd, 2025 · Updated: February 3rd, 2025

References

1. Balk, E. M., Lichtenstein, A. H., Chung, M., Kupelnick, B., Chew, P., & Lau, J. (2006). Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis, 189(1), 19-30.
2. Black, D. S., & Slavich, G. M. (2016). Mindfulness meditation and the immune system: a systematic review of randomized controlled trials. Annals of the New York Academy of Sciences, 1373(1), 13-24.
3. Buxton, O. M., & Marcelli, E. (2010). Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States. Social Science & Medicine, 71(5), 1027-1036.
4. Craft, S., & Watson, G. S. (2004). Insulin and neurodegenerative disease: shared and specific mechanisms. The Lancet Neurology, 3(3), 169-178.
5. DeFronzo, R. A., Ferrannini, E., Zimmet, P., & Alberti, G. (2009). International textbook of diabetes mellitus, two-volume set. John Wiley & Sons. - Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. (2005). The metabolic syndrome. The Lancet, 365(9468), 1415-1428.
6. Guerrero-Romero, F., & Rodriguez-Moran, M. (2011). Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial. European journal of clinical investigation, 41(4), 405-410.
7. Heiss, C., Jahn, S., Taylor, M., Real, W. M., Angeli, F. S., Wong, M. L., ... & Glasser, S. P. (2017). Hypertension, dehydration, and glucose intolerance among southern California fire fighters. Occupational medicine, 67(1), 94-101.
8. Heiss, C., Jahn, S., Taylor, M., Real, W. M., Angeli, F. S., Wong, M. L., ... & Glasser, S. P. (2017). Hypertension, dehydration, and glucose intolerance among southern California fire fighters. Occupational medicine, 67(1), 94-101.
9. Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F., & Dela, F. (2004). Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes mellitus. Diabetes, 53(2), 294-305.
10. Hu, T., Mills, K. T., Yao, L., Demanelis, K., Eloustaz, M., Yancy, W. S., & He, J. (2015). Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. American Journal of Epidemiology, 182(5), 374-384.
11. Knowler, W. C., Barrett-Connor, E., Fowler, S. E., Hamman, R. F., Lachin, J. M., Walker, E. A., & Nathan, D. M. (2002). Reduction in the incidence of type 2 diabetes mellitus with lifestyle intervention or metformin. New England Journal of Medicine, 346(6), 393-403.
12. Qin, L., Li, J., & Wang, W. (2016). Mechanistic insights into the interaction between mitochondrial dysfunction and intact insulin signalling. Endocrine connections, 5(1), R35-R64.
13. Reaven, G. M. (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 37(12), 1595-1607.
14. Ross, R., Janssen, I., Dawson, J., Kungl, A. M., Kuk, J. L., Wong, S. L., ... & Hudson, R. (2000). Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obesity research, 8(6), 452-460.
15. Tinsley, G. M., & La Bounty, P. M. (2015). Effects of intermittent fasting on body composition and clinical health markers in humans. Nutrition Reviews, 73(10), 661-674.
16. Unger, R. H., & Orci, L. (2001). Diseases of liporegulation: new perspective on obesity and related disorders. The FASEB Journal, 15(2), 312-321.
17. Weickert, M. O., & Pfeiffer, A. F. H. (2008). Metabolic effects of dietary fiber consumption and prevention of diabetes mellitus. The Journal of Nutrition, 138(3), 439-442.
18. Weiss, R., Bremer, A. A., & Lustig, R. H. (2016). What is metabolic syndrome, and why are children getting it? Annals of the New York Academy of Sciences, 1281(1), 123-140.
19. Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.
Ali Boukllouâ

Author: Ali Boukllouâ

As a Doctor for Cardiology, Sports and Preventive Medicine, and as an entrepreneur, my mission is to improve health and well-being sustainably for longer, happier lives. At PreventicsOne, I use advanced diagnostics for early disease detection. As Team Doctor at ROWE Racing (GT3), I blend my passion for motorsport with medical expertise to enhance team performance and well-being. With Dogscan, I aim to revolutionize lung cancer detection through the incredible scent capabilities of dogs.

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