Longevity Magazine

Empower yourself with insights for preventive health, wellness and longevity. Explore our latest articles on fitness, personalized medicine, cutting-edge science and strategies to help you live a longer, healthier life.

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Longevity: AI’s First Philanthropic Goal
Lifespan Extension Interventions

5 min read

Longevity: AI’s First Philanthropic Goal

The Impending Global Population CollapseWe all have heard about the overpopulation problem Earth is facing. With so many people it is getting harder and harder to scale resources to meet this growing demand. If someone told us that this growth is only an illusion and that the world population is actually going to decline significantly over the next 100 years. Would that be enough for you to sit up and pay close attention? In contrast to what we thought was going to be the number one problem facing our generation, we might instead have to worry about the rapidly shrinking human population. Scientists today believe that we might have miscalculated the runaway population growth scenario. As evidence they present the total fertility rate (TFR), representing the average number of live children a woman bears. This number has been consistently falling since the 1970s, dropping below the "replacement rate" of 2.1 in more and more countries. The US TFR fell below 2.0 in 1973, the UK in 1974, South Korea in 1984, and China in 1991. Current fertility rates include: South Korea (0.68), Japan (1.37), Iran (1.6), and India (2.0). Projections indicate a significant global population decrease in the coming decades, with some radical estimates suggesting the world population could be as low as one-tenth of its current size in a hundred years, or even 250 million by 2200."There are scenarios that the world population a hundred years on may only be one-tenth of what it is now." - says Dr. Subhash Kak.Increasing Age of the PopulationA shrinking total fertility rate (TFR) implies an increasingly aging population. As per the 2023 census, the US has 17% of the population above the age of 65 that is about 57 Million older adults. By 2040, there will be about 87 Million people in that age group. And if the TFR numbers are to be believed the 87 Million might represent up to 30% of the total US population.“Older Adults Outnumber Children in Nearly Half of U.S. Counties in 2024” - US Census BureauConsequences of aging and low TFRGrowing non-discretionary spending on Medicare, Medicaid, Social Security, and interest payments on national debt are exacerbated by an aging population. "Most of the reason we spend more than we make comes down to exploding non-discretionary spending on Medicare, Medicaid, Social Security, and interest payments on our high national debt", says Drory. Adults aged 65 and older are 18% of the population, but they account for 36% of healthcare spending. Pension systems are designed for a higher ratio of working-age individuals to retirees. As populations age and shrink, these systems become insolvent. "Japan is approaching one working age person for each pensioner and China will soon have one working age person for two pensioners, and clearly these ratios are unsustainable." - says Dr. Kak."Social security is going bankrupt" says Omri Drory.Extending Human HealthspanWe cannot ignore the long-term economic benefits from extending human healthspan. a) Reduced Healthcare Costs and Increased Wealth Accumulation b) Stronger Retirement Systems c) Experienced Workers. Healthy older people spend significantly less on healthcare. A longer period of peak earning potential leads to greater individual wealth and increased investment throughout the economy. If people remain productive longer, they contribute to the economy. Longevity allows the retention of "most experienced and productive workers during their peak contribution years. A single year of life expectancy improvement of the older population can generate economic value equal to 4-5% of annual GDP.Slowing down aging enough to raise life expectancy by just one year is worth $38 trillion to the United States alone. 10 years is worth $367 trillion.", says DroryThe Role of AI in Achieving LongevityAdvances in biotechnology and related interventions might give rise to critical solutions to these impending crises. Drory argues that "keeping people young, healthy and productive can genuinely address some of these challenges." As per him, the issue is not living longer, but "getting old with multiple chronic conditions."  Consequently, longevity technology should aim to extend health span (healthy, productive years), not just the lifespan. "Today, humans live about 15-20 years longer, but we haven’t proportionally increased our health span—the number of healthy, productive years we have", says Drory. While it is clear extending the health span might benefit the human race tremendously; we foresee the use of AI in helping humans overcome personal barriers in achieving longevity. Physiologically, AI can detect symptoms or changes in the human body that can serve as early warning flags. Emotionally, AI can provide support to deal with challenging life situations. Psychologically, AI can provide grounding and non-judgemental outlook that can gently modify behavior. Socially, AI can keep you connected and engaged so that you are not isolated or deprived of attention when you need it. AI is already bringing down the cost of running tasks that only need internet and cloud computing resources. It is not too hard to anticipate that AI products will soon be serving the Longevity needs.For starters, AI can be used to empower people with a comprehensive understanding of their personal health data, giving back full control on the life decisions, which include health and wellness decisions too. From the developments in the field, it is not a far-fetched idea to imagine that AI can be trained to develop a philanthropic personality so that it can interact with humans with deep empathy, care and genuine concern.

Why Longevity Experts Should Care About the Pelvic Floor
Pilates

6 min read

Why Longevity Experts Should Care About the Pelvic Floor

When people think of longevity, they think of brain function, joints, diet... but no one talks about the pelvic floor. The one system that controls mobility, strength, sexual health, and bladder control. The only time we think about it is when a sharp pain starts, and doesn't end. But, it's important to talk about what the pelvic floor is, why it's important in the longevity space, and how it connects to overall health. What Exactly is the Pelvic Floor?This is a group of muscles which support the bladder, bowels, and reproductive organs. Think of that support system between your tailbone in the back, and the pubic bone at the front. Yep, that's it! The bowel-shaped support system that forms a girdle underneath the pelvis, and helps to support your bladder, bowels, and reproductive parts.Because of its position, it directly impacts core strength and stability, bladder and bowel control, sexual function, play posture and lower back health. When the pelvic floor is strong, your organs remain stable and keep working at their best. But if there's a dysfunction? Everything changes…and not for the better.Link Between Pelvic Floor Health and LongevityWhen the pelvic floor is damaged, everything connected to its health is also affected. The most common sign of this is pelvic pain, which is usually masked as chronic back and hip pain. Why? Because this localized pain happens below the belly button, in front or at the back of the pelvic region.It is estimated that pelvic pain affects between 2-10% of men, and 10-15% of women worldwide. This can affect the quality of life in so many ways, including:Increased fallsDecreased mobilityPoor sexual healthPoor bowel/bladder control Basically, storing pelvic muscles means improved physical function into old age.What Causes Pelvic Pain?Dealing with pelvic floor dysfunction is rarely possible without knowing the causes, which include:AgeAs the body grows older, so does everything in it. Sadly, this includes the pelvic floor which can become weakened and more prone to fractures.Uterine FibroidsThese are noncancerous tumours which develop around the wall of the uterus. Because it affects only women, these fibroids can lead to painful intercourse, back pain, and menstrual pain.Irritable Bowel Syndrome (IBS)This digestive problem can cause pain in the lower back area, as well as bloating, diarrhea, or constipation. All of which are associated with severe pain.Pelvic Inflammatory Disease (PID)PID occurs when a woman's reproductive organs are infected, due to complications from sexually transmitted diseases like chlamydia or gonorrhea. One of its side effects include lower abdominal pain which affects the pelvic region too.Pregnancy & ChildbirthPregnancy-related pelvic pain, also known as Pelvic girdle pain (PGP) is something that occurs in 50-75% of women. This is due to the pressure exerted on the pelvic region when the organs are pressed to the back, along with the baby's weight. After childbirth, more than. 25% of women still experience postpartum pelvic pain.What Helps The Pelvic Floor?This particular part of the body has a lot of functions, so when it is affected, everything else is. To combat this, there are certain supplements and therapies that can help to maintain the pelvic floor, and keep it at optimal performance.MagnesiumThis supplement generally helps with rest, sleep, and anxiety. However, it's also good for bowel health, which improves digestion, reduces constipation and prevents bloating. Basically, it helps to relieve any pressure on the pelvic floor caused by IBS.CollagenThis protein is naturally found in the connective tissues of the body, and it aids with joint health and bone development. It also assists with providing strength, offering flexibility and support to the pelvic organs, in order to prevent pelvic organs prolapse (POP).Pelvic Floor ExercisesThese are commonly called kegels, a specialized set of exercises to strengthen the pelvic muscles. A few ways to work the area include:Pause urine flow on the toilet: This pelvic muscle works to control your urethra, and make it more stable. This is also called bladder training.Squeeze your anus in: This also works effectively, and enables the pelvic floor to work properly.For best results, it's great to do these exercises up to 2-3 times a day. Just squeeze the muscles for a few seconds and then release. Rinse and repeat up to 10 times per session.Posture exercisesPelvic floor issues can also be caused by poor posture habits, which usually happen during pregnancy and in older people. That's why experts recommend using yoga balls and pilates classes to help with posture exercises at home. More tools include compression bands and support belts to keep the organs firm and supported.AI-driven Pelvic Wellness AppsLuckily, there are some AI-based wellness apps that help to maintain the pelvic muscles, including:Elvie: A smart trainer app which helps with exercises and personalized training plans for users.Perifit: Uses human feedback to help users understand and monitor their pelvic health contractions. This helps in checking out any abnormalities.The Role of Longevity ExpertsEveryone else focuses on mainstream wellness – women's health, supplement rage, and physical health – but no one pays attention to the pelvic area. It's also an important part of physical health, so more focus should be put into it.Pelvic floor dysfunction is a very hard process to deal with, so it is necessary for its health to be maintained. Let's not wait until there is an issue, before treating the pelvic muscles as an important part of the body.When clients come in, there should be a recommended checklist they can follow to renew and rejuvenate pelvic health. This includes:Postnatal recovery toolsThe pelvic area undergoes a lot of strain and pressure during pregnancy, so postnatal care should involve exercising this area and using posture exercises that help.Annual assessments for pelvic healthJust like annual checks are done for the heart and other important organs, the pelvic area should also be scheduled too. Focused assessments should be done to check for sprains, increased pressure, dislocated areas, and even cracks. The pelvic floor is very important for physical health, and it should be treated as such.Pelvic-aware movement routinesPelvic dysfunction is often disguised as back pain, due to the lack of awareness about this area. So, more pelvic-based routines should be incorporated into wellness plans, in order to minimize the risk of fractures and breakdown. These routines could include pilates, mobility workouts, and stress relief tools.A Stronger Future Starts at the CoreIgnoring the pelvic floor is a gap in the longevity conversation. Neglecting a core area like that could lead to increased falls, mobility issues, back pain, reduced sexual health, and poor bladder control.So, it is important for awareness about pelvic health to be spread across other areas. In fact, it should be included in all aging-related guidance. Let's talk about longevity for pelvic health today!

From bloodwork to DNA to AI and back: my journey to solve a micronutrient mystery
Zinc

5 min read

From bloodwork to DNA to AI and back: my journey to solve a micronutrient mystery

How low zinc levels turned into a detective story about health optimization, genetics — and how to use ChatGPT wisely without falling into traps.Hi, I’m Heiko – coach, biohacker, and micronutrient enthusiast. For years, I’ve been fine-tuning my approach to health and longevity by regularly testing my blood for micronutrient levels. Why? Because I believe that keeping all essential and semi-essential micronutrients in the optimal range gives my body the best possible foundation to thrive — mentally, physically, and emotionally.It’s a proactive strategy inspired by experts like Dr. Helena Orfanos-Boeckel, and it’s shaped how I think about performance, stress resilience, and long-term health.One nutrient I’ve been particularly focused on is zinc. And yet — despite consistent, even high-dose supplementation — my blood levels of zinc just won’t budge into the optimal range. Frustrating? Definitely. But also a great opportunity to dig deeper.That’s how this article came about. After a nudge from Sandra (thanks again!) in the New Zapiens community, I decided to revisit my DNA test from SelfDecode. Maybe the answer to my stubbornly low zinc levels was hiding in my genes?Why is zinc so important?Before we dive into the analysis, let’s take a quick detour: zinc is a true multitasker.It plays a key role in the immune system, supports wound healing, and helps fight infections.It’s essential for protein synthesis, making it crucial for muscle growth and recovery.It influences cognitive function, impacting focus and mood.It acts as a cofactor for many enzymes, involved in metabolism, hormone production, and digestion.And here’s a kicker: If you exercise a lot or sweat frequently (sauna, anyone?), you could be losing significant amounts of zinc.Sounds like something you’d want enough of, right? That’s exactly what I thought — but my levels refused to rise ...Checking my DNA test: no red flags?My first glance at my SelfDecode report:SelfDecode resultSo, no increased requirement according to my genetic data. Hmm.But maybe ChatGPT knows more?I asked whether there are SNPs associated with higher zinc needs.(SNPs = Single Nucleotide Polymorphisms, genetic variations that can influence various bodily processes.)ChatGPT provided a first list of potentially relevant SNPs:Screenshot 2025-04-10 175904.png 176.05 KBNever only ask once, especially with ChatGPT ;) So I asked again if there might be some more SNPs that could be relevant. And ChatGPT listed some more:Screenshot 2025-04-10 180441.png 224.03 KBBased on that, I dug into my SelfDecode data and checked my own genetic variations. And I added all the SNP characteristics that SelfDecode had listed as relevant, even if the overall assessment did not reveal an increased need.Then, I asked ChatGPT to interpret all my individual data.Screenshot 2025-04-10 181041.png 59.84 KBThen I asked ChatGPT to critically review its own assessment.Screenshot 2025-04-10 181228.png 17.69 KBSurprise, surprise: ChatGPT’s analysis and conclusion was quite different from SelfDecode’s!While SelfDecode suggested my zinc needs were typical, some SNPs flagged by ChatGPT pointed to a significantly increased requirement!And then I remembered a phrase from the domain of management theory and practice: Culture Eats Strategy for Breakfast.And I asked myself: What if “Lifestyle Eats Genetics for Breakfast”? So what about exercise and sauna for example?I added details about my workout and sauna routine and asked for an updated recommendation.Screenshot 2025-04-10 181433.png 99.79 KBDone? Hmm… not so fast!The trap of question framingAnother shoutout to Sandra, who reminded me that answers by AI models like ChatGPT are highly dependent on how you phrase your questions.So, I reworded the question: Could it be that the original recommendation was way too low in comparison to standard recommendations?Screenshot 2025-04-10 181633.png 148.02 KBThen, I went the opposite way: Was the updated recommendation too high? Maybe ChatGPT simply added up all effects, without considering overlapping factors?Screenshot 2025-04-10 181807.png 157.65 KBNow I had multiple versions of an answer. Which one should I trust?Guess what I did … of course: I asked ChatGPT: “So, first too low, then too high, now low again, ... what can I believe you?” ;)Screenshot 2025-04-10 181946.png 236.65 KBAnd: Screenshot 2025-04-10 182334.png 62.61 KBI totally agree: blood work is not the truth, but the best approach we have!Conclusion: ChatGPT is a great tool — if you know how to ask and how to interpret and challenge its answers Please keep in mind: Everybody and every body is different.My unique lifestyle, diet, and habits can’t (yet) be fully captured by any AI model.And that’s fine with me. I now have enough information to fine-tune my zinc supplementation approach. Taking also my individual experiences and some hints by Chris Masterjohn into account, I will supplement like this:👉 2×15 mg zinc citrate in the early morning👉 25 mg zinc bisglycinate in the later morningTwo highly bioavailable forms, taken as far away as possible from other minerals (esp. copper) that could block absorption or interact directly.Now, it’s all about testing, measuring, and adjusting again.Will my zinc levels finally move? Or are there other aspects that I don’t know yet?To be continued... 😃

Even chatbots can benefit from mindfulness therapy
Mindfulness

2 min read

Even chatbots can benefit from mindfulness therapy

Time to ease up.Ever wonder if chatbots need therapy, too? New research reveals AI like ChatGPT can feel “stressed” by negative stories—and that might raise serious questions about AI’s emotional stability. It also shows that mindfulness therapy can help chatbots as well.Key facts and findingsEmotional overload: Traumatic narratives doubled GPT-4’s “anxiety levels,” compared to neutral text. Military stories trigger more: Combat experiences elicited the strongest fear responses from the AI. Therapeutic prompts work: Researchers injected mindful, calming text into GPT-4’s chat history—significantly soothing elevated anxiety. Healthcare implications: AI-based therapy tools face constant negative input, so emotional stability is a big deal. Additional context and expert insightWhy does it matter? If an AI assistant “absorbs” user trauma in mental health settings, it risks amplifying biases or responding erratically. According to lead researcher Dr. Tobias Spiller, simple interventions—like breathing and mindfulness prompts—can help keep AI grounded without the pricey burden of retraining models.Looking aheadExpect more studies on how these “therapeutic injections” stabilize AI across longer dialogues and diverse languages. In the meantime, mindful prompt hacks could become a quick win for safer, more reliable AI in therapy tools. Got a chatbot that deals with heavy content? Try slipping in some mental health exercises—your digital assistant might thank you.

A new era for personalized nutrition
AI

2 min read

A new era for personalized nutrition

Bringing advanced data to your dinner plate. What’s happening:Researchers at the University of Illinois Urbana-Champaign have convened top experts and industry leaders to tackle one major question: How can we ensure that personalized nutrition (PN) services—apps, supplements, high-tech “nutrition trackers”—deliver on their big promises? The team, led by professor Sharon Donovan, published two new papers outlining best practices and regulatory considerations so PN can evolve responsibly and transparently. Key findings: Data overload: From continuous glucose monitors generating thousands of data points to advanced genetic and microbiome testing, PN relies on a mountain of personal health information—requiring careful integration and privacy safeguards.Guiding principles: Workshops resulted in frameworks for collecting and fusing data, covering everything from health and behavioral inputs to shopping and dietary patterns.Regulatory gaps: Because PN spans multiple domains (food, supplements, medical devices), current laws don’t always align. Experts say it’s time for updated guidelines that protect users while allowing innovation.Why it matters:Personalized nutrition hinges on analyzing your unique biology and lifestyle to offer targeted diet advice. With global interest in “food as medicine” on the rise, standardized approaches can help ensure these customized recommendations actually improve health and aren’t just hype.Expert take:“PN is incredibly complex—you need consistent methods and trustworthy sources,” Donovan emphasizes. “We aim to be a go-to resource where researchers, companies, and regulators come together and shape the future of personalized nutrition.”Looking ahead:Expect more AI-driven tools and next-gen wearables (e.g., continuous glucose monitors, heart-rate sensors) to gather real-time data.Clearer labeling rules and quality checks are in the works, protecting consumers from misleading claims.For anyone curious, the university offers free online courses in PN as well as a grad certificate—making it easier to dive into this growing field.