Longevity Magazine

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Omega-3 may turn back the epigenetic clock
Omega-3 Fatty Acids
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2 min read

Omega-3 may turn back the epigenetic clock

An unexpected edge for healthy aging. What’s happening:A new Swiss-led clinical trial (DO-HEALTH) found that daily omega-3 supplements could slow down biological aging—at least for healthy adults over 70. Over three years, 777 participants took either 1g of plant-based omega-3, high-dose vitamin D, and/or did simple home workouts (three times a week). Researchers used cutting-edge “epigenetic clocks” (which track DNA methylation) to see how fast participants were aging at the cellular level. Key findings: Omega-3 alone slowed several epigenetic age markers, effectively making cells appear about three months “younger” than those in the placebo group.Combine & conquer: Adding vitamin D plus exercise amplified the anti-aging effect, resulting in four months of slower epigenetic aging.Extra perks: Past DO-HEALTH data linked omega-3 to a 10% reduction in falls and a 13% drop in infection risk among older adults. Even the chance of pre-frailty decreased by 39% when omega-3, vitamin D, and exercise teamed up.Why it matters:Omega-3 has long been hailed for heart and brain benefits. Now, it might help keep your cells younger, too—particularly if you’re combining supplements with movement and vitamin D. Given that aging is a top risk factor for chronic diseases, every month of biological “youth” counts.Expert take:“These effects may seem modest, but if they persist, the impact on public health could be substantial,” says study lead Heike Bischoff-Ferrari, referencing the real-world significance of slowing cellular aging.Looking ahead:Future research aims to identify exactly how omega-3 influences those DNA clocks.While the study focused on Swiss seniors, the results hint at broader possibilities for other age groups.As always, talk to your doctor before jumping on the supplement bandwagon—too much of a good thing can backfire. Still, a bit of healthy fat, sunshine vitamin, and moderate exercise might be your new trifecta for graceful aging.