Magazine | Founder Interview: Max Marchione, Co-Founder and CEO of Superpower

Founder Interview: Max Marchione, Co-Founder and CEO of Superpower

Written by Karol Domagalski 5 min read
Founder Interview: Max Marchione, Co-Founder and CEO of Superpower

In our Founder Interview series, we showcase the brightest minds in preventive health, wellness, and longevity. In Episode 1, we introduce Max Marchione, Co-Founder and CEO of Superpower.

Tell us a little about yourself and your current venture

I'm Max, co-founder of Superpower.com, a new healthcare system to prevent disease and enhance human capabilities. Previously, I built Next Chapter to help shape the trajectory of young talent and Ultraviolet Ventures to invest in companies that ‘nobody else sees’. I dropped out of Australia’s top law school, despite ranking 1st, to study mathematics and statistics while working 10 jobs on the side. Today, I live in San Francisco and spend most of my time thinking about healthcare 5 years from now, resource allocation in light of AI, storytelling, culture, speed, and how to create an A+ team & culture. I invest from pre-idea via Fractal Capital. You can learn more about me at maxmarchione.com 

How do you balance the demands of running a business while maintaining your own health and longevity?

I believe that health is a tool for human performance. You can read my protocol at maxmarchione.com/protocol I've spent lots of time and money optimizing this, so hopefully you don't have to. 

Do you have a personal health goal? What is it? 

Reduce my biological age to under 24. Maintain <12% bf year round. Gut health top 5th percentile. Toxin exposures, bottom 5th percentile. 

Before launching your venture, can you walk us through the “aha” moment that inspired the creation of your product/service?

From a young age, I struggled with health issues. It would take me hours to fall asleep every night, and despite seeing over 20 doctors, undergoing surgery, and being prescribed lifelong medication, no one could work out what was going on. 

So, I explored the world of health myself, reading papers and experimenting with tools like the Gen 1 Oura Ring in 2016 and continuous glucose monitors in 2017—at a time when using these devices was considered weird.

I realized that healthcare should be used not just for treating illness, but for maximizing human potential. I finally found a doctor who got to the root of my health problems, and in doing so, had an important realization: there’s a huge gap between the cutting-edge healthcare available to the elite, like Jeff Bezos, and what the average person receives. 

Since then, I’ve believed that everyone, not just a privileged few, should have access to this kind of care, and that’s what we’re building at Superpower. 

What sets your venture apart in the crowded health and wellness industry?

I'd challenge the premise that the industry is crowded. I think it's just getting started and there is so much whitespace. 

Fundamentally, no one has been able to do what Superpower is doing, which is taking high-end concierge medicine that previously cost $10k-$100k, and making that accessible for a far lower amount. 

No one besides Superpower has aggregated dozens of diagnostics and therapeutics under one roof, and built the AI systems that connect the dots across all of someone's data. 

What’s the most surprising lesson you’ve learned from your customers or users?

We need to obsessively simplify the value proposition. What feels simple to us can still be complex and obscure to users. 

What is the most groundbreaking or unexpected finding in the field of longevity research that you’ve come across recently, and why do you find it so compelling?

My friend has built a ring to continuously monitor hormones, non-invasively. No one knows about this company yet, but it will be huge. 

In your opinion, which emerging longevity trend or product will have the most transformative impact on our health over the next five years, and why?

Gene therapy, and the ability to genetically drive outcomes in a reasonably safe manner. 

One thing you wish more people knew about health and longevity?

That supplements are not the answer. 

What is the biggest longevity myth you’d like to debunk?

That longevity is a noisy and saturated industry. It's not. 

If you could recommend only one supplement for a longer, healthier life, which would it be, and what makes it indispensable?

I'm going to cheat and say this multi-vitamin because it solves for methylation (b vitamins), mineral depletion, antioxidants, vitamin D/K, etc. > Adapt Naturals

How old can we potentially become at maximum?

Probably only 170 without changing our physical bodies or uploading our brains.

What resources (books, podcasts, mentors) have been most valuable in your entrepreneurial journey?

Books: 

  • Dune
  • The Fountainhead
  • Poor Charlie's Almanac

More at footnotes.maxmarchione.com

If there’s one message or insight you’d like readers to take away from your journey, what would it be?

Stop thinking about doing things and just do things. Action produces information. 


Published: January 4th, 2025 · Updated: January 6th, 2025

Author: Karol Domagalski

Family and health first. Big on sports, nutrition, longevity, travel, and all things digital. Founder of New Zapiens, on a mission to help people live their best lives.

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Top health and longevity conferences in 2025

3 min read

Top health and longevity conferences in 2025

Feeling overwhelmed by the sheer number of health and longevity events popping up these days? We get it. It’s enough to make even the most dedicated biohacker’s head spin. So, to help you navigate the ever-expanding landscape of longevity gatherings, we’ve put together a curated guide to the must-attend events of 2025. Think of it as your personal compass for the year ahead in health and longevity. Grab your calendar, your preferred note-taking device, and let’s explore the top events designed to help you live better, longer, and smarter.Find your next learning opportunity, bookmark the relevant links, and don’t forget to bring your intellectual curiosity—2025 is shaping up to be an exciting year for the science of longevity. (and a healthy dose of evidence-based thinking, naturally).JanuaryDon't Die Summit • Saturday 18th • US (Los Angeles)FebruaryDon't Die Summit • Saturday 15th • US (New York)Founders Longevity Forum • Thursday 27th - Friday 28th • SG (Singapore)MarchTurn Around Aging Conference • Friday 14th • DE (Munich)Don't Die Summit • Saturday 22nd • US (Miami)Biohackers World • Saturday 29th - Sunday 30th • US (Los Angeles)AprilFIBO • Thursday 10th - Sunday 13th • DE (Cologne)Health Optimisation Summit • Saturday 12th - Sunday 13th • US (Austin)On Aging • Monday 21st - Thursday 24th • US (Orlando)Bioacking Days • Friday 25th - Sunday 27th • DE (Stuttgart)MayLongevity Med Summit • Tuesday 6th - Thursday 8th • PT (Lisboa)Life Summit • Tuesday 27th - Wednesday 28th • DE (Berlin)Dave Asprey Biohacking Conference • Wednesday 28th - Friday 30th • US (Austin)JuneHOLOLIFE Summit (former Biohacking Summit) • Saturday 14th - Sunday 15th • EE (Tallinn)HLTH • Monday 16th - Thursday 19th • NL (Amsterdam)JulyLongevity Summit Dublin • Wednesday 2nd - Friday 4th • IE (Dublin)Flowfest • Thursday 3rd - Sunday 6th • DE (Munich)RAADfest&nbsp;• Thursday 10th - Sunday 13th • US (Las Vegas)SeptemberBiohacking Festival • Saturday 6th - Sunday 7th • DE (Heidelberg)Biohacking Congress 2025 • Friday 12th - Sunday 14th • DE (Bad Dürrheim)Health Optimisation Summit • Saturday 13th - Sunday 14h • UK (London)Health &amp; Longevity Forum • Thursday 18th - Sunday 21st • CH (St. Moritz)OctoberCopenhagen Health Week • Saturday 4th - Sunday 5th • DK (Copenhagen)NovemberMedica • Monday 17th - Thursday 20th • DE (Düsseldorf)This health and longevity conference calendar is a living document and is updated frequently. If you have a favorite longevity event or summit that's not listed, feel free to contact us via [email protected] and we'll be happy to add it to the list!To a healthy, knowledgeable, and social 2025!

 The Role of Insulin and Insulin Resistance in Longevity

The Role of Insulin and Insulin Resistance in Longevity

Longevity is the ultimate goal for those seeking a longer, healthier, and more fulfilling life. While factors like diet, exercise, and stress management are crucial, the regulation of insulin levels and insulin resistance also play a significant role. But why is this so important, and how can we influence it? This article delves into the scientific foundations of insulin and insulin resistance, explores their impacts on health, and offers practical tips for reducing insulin resistance.&nbsp;What are Insulin and Insulin Resistance?&nbsp;Insulin is a hormone produced in the pancreas that is essential for regulating blood sugar levels. It helps cells in muscles, fat, and the liver absorb glucose from the blood to use as energy or store as glycogen. Insulin plays a crucial role in carbohydrate, fat, and protein metabolism.&nbsp;Insulin resistance occurs when cells in muscles, fat, and the liver do not respond well to insulin, leading to elevated blood sugar levels. This prompts the pancreas to produce more insulin to compensate. Over time, this can result in hyperinsulinemia (excessively high insulin levels) and eventually type 2 diabetes mellitus, heart disease, and other metabolic disorders.&nbsp;Scientific Foundations and Mechanisms&nbsp;1. Insulin and Glucose Homeostasis&nbsp;Mechanism: Insulin regulates blood sugar levels by promoting the transport of glucose into cells. In insulin resistance, however, cells respond poorly to insulin, causing glucose to remain in the blood. This leads to chronically elevated blood sugar levels, which can promote inflammation and oxidative stress.&nbsp;Study: According to DeFronzo et al. (2009), insulin resistance is not just a precursor to type 2 diabetes mellitus, but also a central factor in the development of cardiometabolic diseases like hypertension and atherosclerosis.&nbsp;2. Insulin and Fat Storage&nbsp;Mechanism: Insulin promotes fat storage by inhibiting fat breakdown (lipolysis) and stimulating fat synthesis (lipogenesis). Elevated insulin levels, which are common in insulin resistance, can thus lead to increased fat storage, particularly in the abdominal area.&nbsp;Study: A study by Weiss et al. (2016) showed that insulin resistance and hyperinsulinemia are both causes and consequences of obesity, which in turn increases the risk for cardiovascular diseases.&nbsp;3. Insulin and Cellular Aging&nbsp;Mechanism: Chronically high insulin levels and insulin resistance can accelerate cellular aging by reducing the activity of telomerase (the enzyme that protects telomeres) and increasing oxidative stress. This can lead to accelerated aging of cells.&nbsp;Study: Research by Qin et al. (2016) indicates that insulin resistance and elevated insulin levels promote cellular aging through increased cell damage and age-related degeneration.&nbsp;Insulin Resistance and Chronic Diseases&nbsp;Insulin resistance is directly related to a variety of chronic diseases that can significantly impair quality of life and lifespan. Here are some of these diseases and their connection to insulin resistance:&nbsp;1. Cardiovascular Diseases&nbsp;Elevated insulin levels and insulin resistance are strong predictors of cardiovascular diseases. Insulin resistance leads to increased production of free radicals, which can damage arterial walls and promote inflammatory processes.&nbsp;Study: According to an analysis by Reaven (1988), insulin resistance is the primary cause of metabolic syndrome, a cluster of risk factors for heart disease and stroke. &nbsp;2. Type 2 Diabetes Mellitus&nbsp;Persistent high blood sugar levels due to insulin resistance can exhaust the insulin-producing beta cells in the pancreas, ultimately leading to type 2 diabetes mellitus.&nbsp;Study: Unger and Orci (2001) explain that insulin resistance plays a key role in the pathophysiology of type 2 diabetes mellitus and can cause long-term complications such as kidney failure and neuropathy.&nbsp;3. Obesity&nbsp;Elevated insulin levels favor fat storage, leading to obesity and further metabolic disturbances.&nbsp;Study: Eckel et al. (2005) demonstrate that insulin resistance is both a cause and a consequence of obesity, creating a vicious cycle that is hard to break. &nbsp;4. Neurodegenerative Diseases&nbsp;Recent research suggests that insulin resistance can also increase the risk for neurodegenerative diseases like Alzheimer’s.&nbsp;Study: A study by Craft et al. (2012) shows that insulin resistance and hyperinsulinemia significantly increase the risk for cognitive impairment and Alzheimer’s disease.&nbsp;Practical Tips for Reducing Insulin ResistanceThe good news is that insulin resistance can be reduced through specific lifestyle changes and dietary strategies. Here are some scientifically supported approaches:&nbsp;1. Diet&nbsp;Low-Carb or Ketogenic Diet: A low-carb diet can help lower insulin levels and improve insulin sensitivity. These diets focus on reducing sugar and starchy foods while emphasizing healthy fats and proteins.&nbsp;Study: Hu et al. (2015) found that low-carb diets are effective in controlling blood sugar levels and body weight.&nbsp;Fiber-Rich Foods: Fiber slows the absorption of sugar into the blood and improves insulin sensitivity. Foods such as vegetables, fruits, whole grains, and legumes are high in fiber.&nbsp;Study: Weickert and Pfeiffer (2008) demonstrated that fiber improves metabolic health and reduces the risk of insulin resistance. Specific recommendations include carrots, berries, spinach, and oatmeal.&nbsp;2. Exercise&nbsp;Strength Training: Regular strength training helps build muscle mass and increases muscle insulin sensitivity. This leads to better glucose uptake and lower overall blood sugar levels.&nbsp;Study: Holten et al. (2004) showed that strength training significantly improves insulin sensitivity in patients with type 2 diabetes mellitus.&nbsp;Aerobic Exercise: Aerobic activities such as running, cycling, or swimming improve insulin sensitivity and help regulate blood sugar levels.&nbsp;Study: Ross et al. (2000) found that regular aerobic exercise improves insulin sensitivity in overweight and obese adults. A 30-minute walk after meals could be a practical recommendation.&nbsp;3. Weight Management&nbsp;Weight Reduction: Even moderate weight loss can significantly improve insulin sensitivity and reduce the risk of type 2 diabetes mellitus.&nbsp;Study: Knowler et al. (2002) showed that a weight reduction of just 7% of body weight lowered the risk of developing type 2 diabetes mellitus by 58%. Regular monitoring of BMI and waist circumference can be helpful. &nbsp;4. Sleep&nbsp;Improved Sleep Hygiene: Adequate and high-quality sleep supports metabolic health and can help reduce insulin resistance.&nbsp;Study: Buxton and Marcelli (2010) found that sleep deprivation significantly impairs insulin sensitivity. Specific tips include securing 7-8 hours of sleep and maintaining consistent sleep schedules.&nbsp;5. Stress Management&nbsp;Stress Reduction: Chronic stress can raise insulin levels and lead to insulin resistance. Techniques such as meditation, yoga, and mindfulness can help lower stress levels.&nbsp;Study: Black and Slavich (2016) demonstrated that mindfulness practices improve insulin sensitivity and reduce inflammation.&nbsp;Additional Measures to Improve Insulin Sensitivity&nbsp;1. Intermittent Fasting&nbsp;Intermittent fasting (IF) can be an effective method to improve insulin sensitivity. Various methods include 16:8 (16 hours fasting, 8 hours eating) or 5:2 (5 days normal eating, 2 days calorie restriction).&nbsp;Study: Tinsley and La Bounty (2015) found that intermittent fasting can improve insulin sensitivity and lower insulin levels.&nbsp;2. Nutritional Supplements&nbsp;Certain nutritional supplements have been proven to improve insulin sensitivity, including magnesium, omega-3 fatty acids, and berberine.&nbsp;Magnesium: A study by Guerrero-Romero and Rodriguez-Moran (2011) showed that magnesium improves insulin sensitivity and blood sugar levels.&nbsp;Omega-3 Fatty Acids: According to a meta-analysis by Balk et al. (2006), omega-3 fatty acids improve insulin sensitivity and reduce inflammation.&nbsp;Berberine: A study by Yin et al. (2008) showed that berberine improves insulin sensitivity in patients with type 2 diabetes mellitus.&nbsp;3. Hydration&nbsp;Adequate hydration is also crucial for maintaining healthy insulin sensitivity.&nbsp;Study: A study by Heiss et al. (2017) showed that dehydration can reduce insulin sensitivity.&nbsp;Conclusion&nbsp;Insulin and insulin resistance play a crucial role in health and longevity. Chronically high insulin levels and insulin resistance can lead to numerous health issues, accelerating aging and diminishing quality of life. Fortunately, there are many proven strategies for improving insulin sensitivity and reducing insulin resistance. A combination of a healthy diet, regular exercise, adequate sleep, and effective stress management can significantly enhance health and promote a long, fulfilling life.&nbsp;

Top Longevity Supplements to Support a Longer Life

Top Longevity Supplements to Support a Longer Life

Longevity, the pursuit of living a long and healthy life, is a goal many people strive for. Beyond lifestyle factors such as diet, exercise, and stress management, supplements can also play a role. But which supplements are actually effective, and what does scientific research say about them? In this article, we'll delve into various types of supplements, evaluate their potential benefits and risks, and explain the scientific foundations.What are Supplements?Supplements are products that contain vitamins, minerals, herbs, amino acids, or other bioactive substances and are intended to supplement the diet. They come in various forms, including tablets, capsules, powders, and liquids. Often, they are marketed as a way to fill nutritional gaps and improve overall quality of life.Scientific Foundations and MechanismsThe following overview covers various supplements and their mechanisms that could potentially contribute to longevity:1) Antioxidants&nbsp;Antioxidants are substances that prevent or repair oxidative damage caused by free radicals. Oxidative stress is a major factor in aging and the development of chronic diseases.Key AntioxidantsVitamin C: This water-soluble vitamin has antioxidant properties and supports the immune system. According to a study by Carr and Frei (1999), vitamin C can help reduce oxidative stress.Vitamin E: A fat-soluble antioxidant that protects cell membranes. The study by Traber and Stevens (2011) shows that vitamin E can minimize cell damage from free radicals.Coenzyme Q10 (CoQ10): This molecule plays a key role in energy production and has strong antioxidant properties. The study by Crane (2001) highlights the benefits of CoQ10 for cellular energy and antioxidant protection.2) Omega-3 Fatty Acids&nbsp;Omega-3 fatty acids are polyunsaturated fats that reduce inflammation and promote heart health.Key Sources and StudiesEPA and DHA: These long-chain omega-3 fatty acids from fish oil have anti-inflammatory properties and can improve heart health. A meta-analysis by Mozaffarian and Rimm (2006) shows that regular fish oil intake can significantly reduce the risk of cardiovascular diseases.ALA: A short-chain omega-3 fatty acid found in plant sources like flaxseed and chia seeds. A study by Pan et al. (2012) shows that ALA also has anti-inflammatory effects and can reduce the risk of heart disease.3) Vitamins and Minerals&nbsp;Vitamins and minerals are essential nutrients necessary for numerous biological functions.Key Vitamins and MineralsVitamin D: This vitamin is crucial for bone health and the immune system. The study by Holick (2007) shows that vitamin D deficiency is associated with a higher risk of various chronic diseases.Magnesium: A mineral important for muscle function, nerve transmission, and energy production. According to a study by Swaminathan (2003), adequate magnesium intake can improve insulin sensitivity and reduce the risk of type 2 diabetes.Zinc: An essential trace element for the immune system and DNA synthesis. Studies have shown that zinc positively affects immune function and wound healing (Prasad, 2008).4) Adaptogens&nbsp;Adaptogens are plant-based substances that help the body manage stress and promote homeostasis.Key Adaptogens and StudiesAshwagandha: This herb is used in Ayurvedic medicine for its stress-reducing properties. A study by Chandrasekhar et al. (2012) shows that Ashwagandha can lower cortisol levels.Rhodiola Rosea: Known for its anti-fatigue and stress-reducing effects. The study by Panossian et al. (2010) emphasizes the benefits of Rhodiola Rosea in improving mental and physical performance.Ginseng: Another prominent adaptogen that can enhance stress tolerance and physical endurance. Studies have shown that ginseng can improve mental and physical performance (Reay et al., 2005).5) Polyphenols&nbsp;Polyphenols are powerful antioxidants found in plants that have anti-inflammatory and antiviral properties.Key Polyphenols and StudiesResveratrol: A polyphenol found in red wine and grapes, linked to extended lifespan. A study by Baur et al. (2006) shows that resveratrol can extend the lifespan of mice and have positive effects on mitochondrial function.Curcumin: The active component of turmeric with potent anti-inflammatory and antioxidant properties. The study by Aggarwal et al. (2007) highlights that curcumin can help in the prevention and treatment of a variety of inflammatory diseases.EGCG (Epigallocatechin gallate): A potent antioxidant found in green tea with anti-inflammatory properties. Studies have shown that EGCG can reduce the risk of various chronic diseases (Bettuzzi et al., 2006).6) Probiotics&nbsp;Probiotics are living microorganisms that promote gut health by supporting the microbial balance in the intestines.Key Probiotics and StudiesLactobacillus and Bifidobacterium: These bacterial strains are commonly found in probiotic supplements. A study by Sanders et al. (2013) shows that probiotics can improve gut health and strengthen the immune system.Synbiotics: Combination of probiotics and prebiotics that work synergistically to promote gut health. The study by Markowiak and Śliżewska (2017) emphasizes the benefits of synbiotics in improving gut flora and overall health.7) NAD+ (Nicotinamide adenine dinucleotide)&nbsp;NAD+ is a coenzyme that plays a central role in energy metabolism and cellular repair. It is essential for the function of enzymes called sirtuins, which are involved in regulating longevity.Key Sources and StudiesNMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside): These precursors to NAD+ can boost NAD+ levels in the body. A study by Mills et al. (2016) showed that NMN supplementation can delay aging-related symptoms in mice.Increasing Cellular Energy: NAD+ contributes to ATP production, which is essential for cellular processes. A study by Yoshino et al. (2011) showed that increasing NAD+ levels improves mitochondrial function and insulin sensitivity.8) Amino Acids&nbsp;Amino acids are the building blocks of proteins and play a crucial role in many biological processes, including muscle protein synthesis and energy metabolism.Key Amino Acids and StudiesLeucine: This essential amino acid is known for its role in muscle protein synthesis. A study by Wilkinson et al. (2013) showed that leucine can promote muscle regeneration and growth.Glutamine: A non-essential amino acid important for gut health and the immune system. Studies have shown that glutamine can improve gut barrier function and support recovery after intense training (Wang et al., 2015).9) SeleniumSelenium is an essential trace element that supports antioxidant enzymes like glutathione peroxidase, which protect against oxidative stress.Key Sources and StudiesDietary Sources: Selenium can be found in nuts (especially Brazil nuts), seafood, and meat.Studies: A study by Rayman (2012) shows that adequate selenium intake is associated with better immune function and lower mortality rates.10) Alpha-Lipoic Acid (ALA)&nbsp;Alpha-lipoic acid is a fatty acid-like compound that is both water- and fat-soluble and has strong antioxidant properties.Key Sources and StudiesEffects: ALA can regenerate other antioxidants such as vitamins C and E and improve mitochondrial function.Studies: A study by Shay et al. (2009) shows that ALA has the potential to reduce oxidative stress and improve insulin sensitivity.Risks and ConsiderationsWhile many supplements offer potential benefits, it is important to be aware of the risks. Some supplements can interact with medications or be toxic in high doses. For example, excessive amounts of fat-soluble vitamins (like vitamins A and E) can be toxic. Therefore, it is recommended to consult with a healthcare provider or nutritionist before starting any new supplements.Future of Supplement ResearchResearch into the benefits of supplements for longevity is a dynamic and growing field. New discoveries and scientific breakthroughs can lead to a better understanding of the mechanisms by which these products work. In future articles, we will delve deeper into the specific benefits of individual supplements and present the latest scientific findings on how they can promote longevity.ConclusionSupplements can make an important contribution to promoting longevity by reducing inflammation, providing antioxidant protection, and supporting overall health. However, it is essential to rely on scientifically validated products and maintain a balanced diet and healthy lifestyle. In future articles, we will explore specific supplements and their particular benefits for longevity in more detail.