Longevity Magazine

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Discover your molecular profile: a gentle introduction to MOLEQLAR’s EPI-Proteomics Test
Sponsored
Biomarkers
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9 min read

Discover your molecular profile: a gentle introduction to MOLEQLAR’s EPI-Proteomics Test

Have you ever wondered how your day-to-day habits—like what you eat, how often you exercise, or even how much stress you carry—actually shape your body at the molecular level? We often hear that diet and lifestyle can affect our health, but connecting those dots can feel vague or distant. That’s where MOLEQLAR’s EPI-Proteomics Test comes in, offering a closer look at „your molecular profile” by measuring the proteins inside your cells. By highlighting trends in everything from vitamin turnover to your body’s pace of aging, this test can serve as a helpful guide when you’re aiming for a healthier, more balanced life.A fresh perspective on biological age Traditional tests might focus on DNA methylation to estimate biological age, but the EPI-Proteomics Test uses a different approach. Instead of zooming in on genetic “volume controls,” it analyzes the proteome—the total set of proteins in your cells at any given moment. Why does that matter? Proteins reflect the real-time state of your body. They can shift quickly with changes in diet, stress levels, and exercise habits, offering a dynamic snapshot of how your lifestyle translates into concrete biological effects.What is ProteoAge?Imagine looking beyond the simple tally of birthdays and peering into the microscopic world where your cells actually ‘live’ and ‘work.’ That’s precisely what ProteoAge measures: how old your body is on a molecular level, rather than on a purely chronological one. By analyzing thousands of protein signals, it becomes possible to determine how effectively cells are functioning at any given moment. Two people might share the same birth date, yet the one with a lower ProteoAge could feel more energetic, stay active longer, and generally enjoy better vitality. By understanding your ProteoAge, you gain a clearer picture of your inner fitness—empowering you to shape your lifestyle in a way that supports a healthier, more resilient you. Similar in principle, different in practiceEpigenetic tests commonly rely on methylation patterns in blood or saliva to gauge how lifestyle factors affect aging, whereas MOLEQLAR’s EPI-Proteomics Test measures proteins in cheek cells. The principle is broadly alike—unhealthy habits can raise your “age” while healthier routines tend to lower it—but the specific metrics and analytical methods differ. Although the results aren’t directly interchangeable with those from DNA methylation tests, both approaches can shed light on whether your day-to-day choices are boosting or undermining your molecular well-being.Why proteomics? Think of it like your personal gardenImagine your body as a thriving garden, where your genes act as seeds holding the potential to grow into various types of “plants.” Proteomics represents the actual garden at any given moment: which plants are sprouting, how robustly they’re growing, and how they respond to changes in sunlight, water, or soil quality. This real-time view reveals how factors like your diet, stress levels, and exercise habits help certain plants flourish—or cause weeds (negative processes) to spread.Epigenetics meets proteomics: why your daily choices matterIn this garden, epigenetic processes are like the gardener, deciding how much water, fertilizer, or shade each seed receives. If you’re sleep-deprived or frequently stressed, the gardener may unintentionally favor “inflammation” or “stress-response” plants, letting them crowd out the healthier growth. On the other hand, a balanced lifestyle—including regular workouts and nutrient-rich meals—can encourage more robust “muscle repair” or “energy metabolism” plants to thrive.By measuring which “plants” are actually present and active, proteomics shows the direct outcome of these epigenetic gardening choices. Over time, consistent care steers your garden toward a flourishing landscape, while neglect or poor habits can leave it wilted and overrun. Essentially, epigenetics sets the guidelines on how seeds can develop, and proteomics captures how those guidelines play out—offering a clear snapshot of your health at the cellular level. What the test reveals Biological age & pace of aging Through thousands of protein measurements in your cheek swab, the EPI-Proteomics Test estimates both your biological age and the speed at which you’re aging. This data offers insight into whether your lifestyle choices might be speeding things up—or, ideally, slowing things down. Nutritional health score Proteins shift in response to what you eat. By measuring specific markers tied to macronutrients (like carbohydrates, fats, and proteins) and micronutrients (like zinc or vitamins A and D), the test provides a Nutritional Molecular Score. The score indicates how closely your diet aligns with healthier patterns, guiding you toward small yet effective tweaks if you’re off-track—such as cutting down on sugary drinks or increasing vegetable intake. Sport & activity insights If you’re curious about whether your exercise routine is pushing you closer to a “healthy” zone or whether you could benefit from a broader range of activities (like more strength training or extra rest days), the test’s Sport Molecular Score can help. It compares your proteomic markers against those of individuals with varying degrees of physical activity and suggests ways to refine or expand your routine.Detailed biomarkers Beyond giving you an overall health score, the EPI-Proteomics Test pinpoints specific protein markers linked to: Vitamin E turnover: Adequate vitamin E utilization helps protect cells from oxidative stress—a factor that can accelerate the aging process. Cholesterol metabolism: Efficient cholesterol handling promotes cardiovascular health, which in turn supports a slower pace of biological aging. Sirtuin expression: Sirtuins govern key processes like DNA repair and metabolic regulation, making their balanced activity crucial for healthy aging. Inflammatory response: Keeping inflammation in check helps prevent chronic stress on the body, which can hasten age-related decline. Sugar regulation: Stable blood glucose levels reduce metabolic strain, potentially slowing down the cellular wear and tear that speeds up aging. Immune activation: A well-tuned immune system fends off illness and maintains tissue health, both of which contribute to healthier aging overall. And more… Molecular insights, not a medical diagnosis It’s important to note that this test doesn’t diagnose medical conditions. Instead, it acts like a map—helping you see how your current lifestyle choices may be shaping your unique molecular landscape. With that information, you can decide if you want to adjust your habits, whether by incorporating more plant-based meals, tweaking your workout schedule, or focusing on better sleep hygiene.Taking the test: a simple cheek swabSome tests rely on blood samples to measure broad markers. By contrast, the EPI-Proteomics Test uses a non-invasive cheek swab. Scientists then analyze thousands of proteins from your buccal cells using advanced mass spectrometry techniques. Because these proteins reflect day-to-day changes, re-testing after a few months can show whether your new dietary or fitness routines are indeed making a difference at the molecular level. Personalized results and actionable advice Your test results don’t just stop at numbers. You’ll receive:Scores for both nutrition and activity, comparing your results to a wider population. Suggestions on improving aspects of your daily life (e.g., lowering processed meat intake, trying new exercise forms, or balancing vitamin levels) based on how far your markers deviate from a healthier range. This structured feedback aims to inspire realistic, incremental change—rather than overwhelming you with drastic, unsustainable goals. Achieving long-term well-being often involves modest steps that gradually shift your habits in a more positive direction.Discover your personal hallmarks of agingImagine wrinkles and slowing reflexes as just the “cover story” of growing older. Behind the scenes, there’s a rich tapestry of twelve distinct cellular processes—from DNA stability and nutrient sensing to how your cells dispose of everyday “trash”—that all play roles in how quickly (or slowly) your body shows signs of wear. These interconnected mechanisms are collectively known as the hallmarks of aging.The good news? MOLEQLAR’s EPI-Proteomics Test goes beyond measuring your ProteoAge: it also offers a personalized glimpse into these hallmarks, helping you see which areas might need extra support. By exploring these molecular “checkpoints,” you gain a deeper understanding of what keeps you feeling energetic and resilient—and how small, science-backed changes in your daily routine might help slow the clock on aging.Compound biomarkers: a more robust approachWhile many tests focus on single proteins as standalone indicators, MOLEQLAR introduces the concept of compound biomarkers for deeper, more reliable insights. Rather than relying on individual protein measurements in isolation, multiple proteins are pooled and cross-validated to form a more comprehensive data set. This methodology applies not only to specific biomarker categories but also extends to ProteoAge and the hallmarks of aging. By analyzing clusters of data points rather than single markers, the resulting information offers a more accurate reflection of overall cellular function—ultimately making test results more meaningful for users.A small, yet significant step toward healthier aging Non-invasive sampling: No blood draw required. Comprehensive data: Thousands of protein markers analyzed. Lifestyle focus: Nutrition, activity, and overall well-being rather than clinical diagnoses. Custom recommendations: Real-world tips to help you align your daily habits with your cells’ needs. For anyone wanting a more concrete roadmap to a healthier life, the EPI-Proteomics Test can be a valuable checkpoint. It provides the “why” behind simple lifestyle changes and sets measurable milestones for you to hit along the way.Final thoughtsUnderstanding your body at the protein level can transform how you view your current habits—revealing whether you’re steadily nurturing your future health or inadvertently undermining it. By marrying complex lab science with practical feedback, MOLEQLAR helps to discover „Your molecular profile“ with a EPI-Proteomics Test, which may guide you toward the small, consistent lifestyle adjustments that could yield big benefits down the road.  Disclaimer: This advertorial is for informational purposes only and does not substitute medical advice. The EPI-Proteomics Test provides insight into lifestyle and biological patterns but is not designed to diagnose or treat any medical conditions. Always consult a qualified healthcare professional before making significant changes to your diet, exercise routine, or supplement regimen. 

How NAD supplements may support healthy aging — and how MOLEQLAR fits in
Sponsored
NAD+
•

10 min read

How NAD supplements may support healthy aging — and how MOLEQLAR fits in

Have you ever wondered why some people maintain high energy levels, mental clarity, and overall vitality as they get older? For many years, scientists have been investigating that question by looking into nicotinamide adenine dinucleotide, commonly abbreviated as NAD+ or simply NAD. This tiny coenzyme seems to play a big role in healthy aging—supporting everything from DNA repair to energy production—and it has become one of the most researched molecules in longevity science.Below, we’ll explore what NAD is, why its levels naturally decline with age, and how the brand MOLEQLAR offers a multifaceted approach with its regeNAD (NAD Regenerating Complex). While NAD+ might be a central piece of the longevity puzzle, remember that no single supplement is a magic bullet. The goal is to better understand the science behind NAD+ so you can make informed decisions about your health and wellness journey.NAD+ 101: The basicsWhat exactly is NAD?NAD stands for nicotinamide adenine dinucleotide, a molecule composed of two mononucleotides linked together via a chemical bond. You’ll find NAD in almost all of your cells, acting somewhat like a co-pilot (a “coenzyme”) to hundreds of different enzymes. Without NAD’s electron-carrying capabilities, many metabolic processes in the body would slow down or halt altogether.NAD+ vs. NADHNAD+ is the oxidized form of the molecule, ready to pick up electrons.  NADH is the reduced form, loaded with electrons to donate.  In your mitochondria—often called the “power plants” of the cell—NADH hands off electrons to the electron transport chain, thereby facilitating the production of ATP (adenosine triphosphate). This ATP powers nearly every cellular activity you undertake, from muscle movement to nerve signals.Why the buzz about NAD levels?NAD levels appear to decline with age, which some researchers believe could be a major driver of metabolic sluggishness, decreased cellular repair, and increased susceptibility to age-related disorders. In various animal models, boosting NAD+ leads to improved insulin sensitivity, cognitive function, and even lifespan extension. Early human studies have shown similarly promising, though not yet conclusive, results. This has fueled a surge of interest in ways to maintain or increase NAD+ levels through diet, lifestyle changes, or targeted supplementation.A brief historical perspectiveEarly discoveries1906: Scientists Arthur Harden and William Young first described NAD in the context of alcoholic fermentation. Interestingly, NAD is involved in both alcohol production (during fermentation) and its breakdown in the body.  1930s: Otto Warburg demonstrated NAD’s significance in redox reactions, which are electron-exchange processes fundamental to energy production in cells and to various industrial applications (like pyrotechnics and margarine manufacturing).From DNA repair to “Longevity Genes”1960s: Researchers discovered NAD’s involvement in DNA repair, specifically with enzymes known as PARPs (poly(ADP-ribose) polymerases).  Modern Focus—Sirtuins: NAD’s popularity today largely stems from its role in activating a family of enzymes called sirtuins (SIRT1–7). Sirtuins are sometimes referred to as “longevity genes” because they influence cellular metabolism, stress responses, and genetic stability. When NAD+ levels are high, sirtuins function more optimally.Niacin: The first cholesterol-lowering “Medication”Long before statins and PCSK9 inhibitors, high-dose niacin (a precursor of NAD) was used in the 1950s to reduce LDL cholesterol levels. This historical tidbit underscores the complexity of vitamin B3-related compounds and their importance to human health—even before scientists fully grasped NAD’s extensive role.Why NAD+ declines with ageIt’s well established that NAD+ levels drop significantly over time, but researchers propose several converging factors:Reduced Production: Key enzymes and precursors for NAD+ synthesis, such as NAMPT and certain forms of vitamin B3, may become less abundant as we age.  Increased Breakdown: Enzymes like CD38 and overactive PARPs can speed up NAD degradation. Chronic low-grade inflammation (“inflammaging”) can further elevate CD38 levels.  DNA Damage and Cell Stress: Accumulated DNA damage triggers more frequent use of NAD in repair processes, depleting available supplies.Potential benefits of higher NAD+Scientists have studied NAD’s role in many tissues, often focusing on how supporting NAD+ might promote “healthspan”—the years of life lived in good health rather than just lifespan.Brain and Cognitive Function: NAD+ is critical for mitochondrial performance within neurons. Some studies suggest improving NAD+ levels may support memory, reduce age-related cognitive decline, and even offer mild protection against noise-induced hearing loss.  Muscle Performance: Muscle cells require ample ATP, which depends on robust mitochondrial function—and thus NAD+. Animal models repeatedly show enhanced muscular endurance and strength when NAD+ is supported through supplementation or genetic manipulation.Heart Health: The heart’s endurance is unmatched—beating more than a billion times in an average lifespan. High concentrations of mitochondria (and the NAD+ they rely on) help maintain the consistent contractions. Early findings indicate that boosting NAD+ in older animals can improve cardiac function and resilience.Liver and Detoxification: The liver handles energy storage, protein synthesis, and detoxification. All these processes depend on enzyme systems that require NAD. It follows that higher NAD+ may support more efficient detox pathways.Immunity and Viral Defense: During certain viral infections, NAD helps fuel specific subsets of PARP enzymes that bolster cellular immunity. Researchers investigating SARS-CoV-2 noted that higher NAD+ levels might support antiviral responses—though the evidence is preliminary and may not generalize to all viral infections.‘Longevity Genes’ and the Hallmarks of Aging: Sirtuins, often called “longevity genes,” appear to rely on NAD+ to modulate multiple hallmarks of aging, including DNA repair, inflammatory pathways, and stress responses. By ensuring adequate NAD, you potentially influence a broad suite of age-related processes.Introduction to MOLEQLAR’s regeNAD (NAD Regenerating Complex)MOLEQLAR, a company dedicated to advanced nutrition and longevity research, has developed regeNAD (NAD Regenerating Complex) to tackle the multifaceted nature of NAD+ metabolism. Rather than depending on a single ingredient, regeNAD supplies various vitamin B3 derivatives—most notably nicotinamide D-ribose, which has garnered attention for its potentially greater efficacy compared to plain nicotinamide (Nam).While nicotinamide and nicotinic acid (niacin) remain valuable for feeding the Salvage and Preiss-Handler pathways, respectively, the inclusion of nicotinamide D-ribose offers a more direct route to key NAD+ intermediates. This shift responds directly to critiques that highlight the need for advanced forms of B3 beyond simple nicotinamide.Additionally, regeNAD includes L-tryptophan to support the De Novo pathway, vitamin B6 to facilitate NMN conversion into NAD+, and apigenin, an ingredient that may help inhibit CD38—a major contributor to NAD+ breakdown. Together, these components aim to optimize multiple steps of NAD+ metabolism, reflecting the growing consensus that targeted approaches like nicotinamide D-ribose can be more effective than relying solely on standard forms of vitamin B3.Spotlight on RiaGev®RiaGev is a proprietary blend of D-ribose and nicotinamide designed to support NAD+ biosynthesis and antioxidant capacity. A 2022 study published in Nutrients found that RiaGev supplementation in overweight or obese adults significantly increased NAD+ and glutathione levels, suggesting enhanced cellular energy metabolism and improved redox balance. These findings point to RiaGev’s potential role in maintaining metabolic health, particularly in individuals seeking targeted approaches to bolster NAD+ status.Don’t Miss Niagen® NR (NR plus TMG)Alongside regeNAD, MOLEQLAR also offers Niagen® NR, available as NR plus TMG Capsules. Niagen® is a branded form of nicotinamide riboside, one of the best-researched vitamin B3 derivatives. Studies have shown that NR can effectively raise NAD+ levels in humans, with potential benefits for metabolic function, cognitive support, and cellular resilience. Coupled with trimethylglycine (TMG), this formulation aims to enhance methylation processes—another factor that influences gene expression and overall metabolic health.Whether you choose regeNAD or Niagen® NR+, MOLEQLAR’s product range underscores the company’s commitment to clinically tested solutions for healthy aging. RiaGev® in regeNAD and Niagen® NR both align with the latest research on how best to maintain robust NAD+ levels. More than supplements: The holistic approachA holistic approach to healthy aging goes beyond simply taking supplements. Regular exercise, for instance, is known to upregulate the enzyme NAMPT, which indirectly helps maintain NAD+ levels. Intermittent fasting or caloric restriction may also support NAD+ by boosting sirtuin activity and reducing inflammation. In addition, a balanced diet that includes vitamin B3-rich foods (such as fish, meat, and whole grains) and amino acids like L-tryptophan can provide the essential building blocks for NAD+ synthesis. Before making any major changes—be it dietary shifts or supplementation—it’s helpful to establish a baseline. To this end, MOLEQLAR has teamed up with the University of Vilnius to develop an at-home NAD test kit. By using a simple dry blood sample, the kit measures your current NAD+ levels, allowing you to track how these levels respond to different interventions and helping you identify the most effective strategies for your individual needs. In addition to regeNAD, MOLEQLAR offers other products, such as the Fasten-Bundle, which includes compounds like Glucosamin, Berberin, and Spermidin to support various molecular aspects of fasting. Although these are not directly related to NAD+ metabolism, they can enhance an overall approach to metabolic health by assisting the body in managing stress responses, insulin sensitivity, and cellular maintenance.Is NAD+ the “Fountain of Youth”?While high NAD+ levels correlate with numerous markers of robust aging, we must remember that no single supplement can replace a healthy lifestyle. The field is still evolving, with plenty of unanswered questions about the interplay between inflammation, CD38 levels, sirtuin activation, and NAD metabolism. Future research may further clarify the best methods, dosages, and timing for NAD+ support.Here’s what we do know:NAD+ is fundamental to processes like cellular energy, DNA repair, and immune defense.  Levels drop with age, and this decline often coincides with reduced metabolic health and resilience.  Boosting NAD+ — by slowing its breakdown, providing enzymatic cofactors, and ensuring adequate precursors — seems to help maintain various aspects of healthspan in animal models and early human trials.  MOLEQLAR’S regeNAD stands out for embracing multiple pathways and steps in NAD synthesis and breakdown. Though no approach guarantees the proverbial “fountain of youth,” a well-rounded regimen that includes a balanced diet, regular exercise, good sleep, and thoughtful supplementation could tip the scales in favor of better aging.Final thoughtsNAD+ is more than just another health buzzword. Decades of biochemical and clinical research underscore its importance in keeping our cells running smoothly — especially as we grow older. Understanding NAD’s history, its complex web of pathways, and the factors that cause its decline allows us to make more nuanced choices about how to support healthy aging.MOLEQLAR recognizes the multi-faceted nature of NAD+ metabolism, which is why it developed regeNAD (NAD Regenerating Complex) to cover many bases—precursor supply, enzyme support, and breakdown inhibition. If you’re curious about how your NAD+ level shapes your daily life, consider measuring it using their at-home NAD test kit, then consult with a healthcare professional to figure out the best approach for your unique situation.Disclaimer: This advertorial is for informational purposes only and does not constitute medical advice. Always speak with a qualified healthcare provider before starting any new supplement, especially if you have underlying health conditions or take other medications. Results may vary, and research on NAD+ continues to evolve.