Magazine | Probiotics: is your gut the gateway to longevity?

Probiotics: is your gut the gateway to longevity?

Written by Volker Blasek 13 min read
Probiotics: is your gut the gateway to longevity?

Do you ever catch yourself wondering if there’s a secret ingredient that could help you live not just longer, but better? For quite a few people, probiotics have started to look like one of those mysterious, possibly magical ingredients. They’re in everything from pricey supplements to your friend’s homemade sauerkraut. But do they actually help extend our lifespans or improve our “healthspans”? In this article, we’ll dive into what probiotics are, how they might—or might not—keep you feeling youthful, and how to integrate them into your life in a smart, practical way.

You know, “live microorganisms” doesn’t exactly sound like a huge selling point at first glance. But once you peel back the layers of marketing hype, probiotics often stand out as a fascinating intersection of gut health, immune function, and the quest for longevity. And by “longevity,” I mean not just clocking more years but possibly spending those years feeling good. So let’s see what the science says so far, shall we?

A quick refresher: what are probiotics?

Probiotics are basically good bacteria (and sometimes yeast) that you can ingest through fermented foods—like yogurt, kefir, or kombucha—or through dietary supplements. They help maintain or restore the balance of beneficial bacteria living in your digestive system, collectively known as your gut microbiota. Think of your gut as a bustling metropolis of microbes that work hand in hand to help you digest food, regulate your immune system, and even produce certain vitamins. When something upsets this balance—antibiotics, stress, poor diet—adding probiotics may help tip the scales back toward harmony.

Common strains you might see on supplement labels include Lactobacillus (often credited with helping lactose digestion and reducing IBS symptoms), Bifidobacterium (seen in some studies to reduce gut inflammation and support bowel regularity), and even yeast-based probiotics like Saccharomyces boulardii. Each has its own superpowers (and limitations). Still, not all claims are as magical as the glossy marketing might lead you to believe.

The aging connection: why gut health matters

As we grow older, a lot of changes happen in the body—some subtle, some not so subtle. One of these changes is a shift in the composition of our gut microbiota. Scientists call the gradual decline in immune function “immunosenescence,” a term that sounds almost futuristic—though the process itself is very real and somewhat inevitable. Over time, the gut can become less diverse, harbor more harmful bacteria, and contribute to inflammation. This type of chronic, low-grade inflammation can potentially set the stage for age-related health problems like cardiovascular disease, metabolic disorders, and even certain neurodegenerative conditions.

So where do probiotics fit into this? Some strains are thought to counteract these age-related changes by supporting immune function and reducing inflammation markers. A couple of studies focusing on Bifidobacterium longum—a strain of bacteria often found in the gut—suggest it may have anti-inflammatory properties that could protect against the wear and tear of aging. This might translate into better cardiovascular health, fewer chronic infections, and who knows, maybe even a bit more pep in your step. Of course, it’s crucial to remember that research is still ongoing and no single strain is a magic bullet for halting the aging process altogether.

The inflammation factor: a key to aging

Inflammation is that double-edged sword. On the one hand, it’s part of the body’s normal defense system; on the other, chronic inflammation is like a fire that never fully goes out. Probiotics might help by fortifying the gut barrier—essentially strengthening your internal walls so that harmful microbes can’t spark the kind of inflammation that slowly wears down tissues. Certain probiotic strains, particularly Lactobacillus reuteri and Bifidobacterium longum, have shown promise in reducing inflammatory markers in some studies.
Now, I’m not saying that by chowing down on miso soup you’ll automatically stave off every ailment linked to aging. But these microorganisms could be one helpful piece of the puzzle. Remember that longevity is about the cumulative effect of many lifestyle factors—exercise, genetics, sleep quality, social support—and possibly your gut microbiota, too.

Probiotics supporting gut–brain axis and gut–skin axis

It’s wild how interconnected our bodies are. For instance, the gut–brain axis is a hot topic right now. The microorganisms in your gut can influence neurotransmitter production, potentially impacting your mood and cognitive function. Older adults sometimes experience a decline in mental sharpness, but some research suggests that maintaining a healthy microbiome might help support cognitive clarity. It’s sort of like giving your brain a friendly little handshake from the gut.

Meanwhile, the so-called gut–skin axis is another area generating excitement. Certain probiotics may lessen systemic and brain inflammation, which then translates into better skin barrier function. That could mean fewer outbreaks of atopic dermatitis, speedier healing of small lesions, or just a generally more vibrant complexion. And although looking youthful isn’t the same as feeling youthful, let’s be honest—most of us wouldn’t say no to a healthy glow as we age.

The skeptical edge: marketing hype vs. reality

All right, let’s switch gears from starry-eyed optimism to a more critical vantage point. Despite the promising findings, the probiotic industry has faced its fair share of skepticism and controversy. One major sticking point is that many over-the-counter probiotic products lack the rigorous scientific validation they tout. Some are basically glorified drinks with generic bacteria strains that haven’t been tested in humans. There’s a lot of guesswork. One expert cited in the research points out that “you can’t lump everything into the same category. Not all of them are good for everything.”

So if you’ve ever seen a commercial claiming Product X can “fix your gut, boost your brain, and help you lose 50 pounds by next week,” you might want to dial down the excitement (I mean, you knew that, right?). Indeed, a more realistic approach is to look for well-studied strains, read the label carefully, and temper your expectations. A beneficial probiotic might help tilt the scales toward better gut health, but it’s definitely not a one-size-fits-all miracle cure.

Current research of probiotics: where things stand

Although the science of probiotics has been studied for decades, it’s still relatively new in the context of longevity. A number of small human and animal studies have highlighted potential benefits tied to improved immune function, reduced inflammation, and a healthier gut environment, but large-scale or long-term clinical trials are needed to really nail down the details. It’s like we have these intriguing puzzle pieces—lower cholesterol here, better immune markers there—yet we haven’t fully connected them to see the complete picture.

Scientists are also curious about how specific probiotic strains co-exist with each other and with the existing gut microbiota. For example, certain variants of Bifidobacterium longum appear to adapt genetically for better “fitness” in the gut, which may give them staying power to exert beneficial effects. But your neighbor’s gut might be an entirely different microbial ecosystem, so a strain that works wonders for you might have minimal effect on them. That’s why some research is pointing toward localized, or region-specific, probiotic strains.

Where to buy: a brief overview of probiotic brands

If you’re exploring supplements or specialized products, here are a few brands that offer probiotic solutions. This isn’t an endorsement or a ranked list—just a neutral snapshot so you know some places to look. Always consider talking to a healthcare professional before trying a new supplement:

  • Avea: Avea provides probiotic supplements that focus on well-studied strains. Their product line may include different formulations targeting gut balance and overall wellness.
  • Mikroveda: Mikroveda offers a range of fermented goods and supplements designed for daily use. Some include mixed strains aimed at promoting a diverse gut microbiome.
  • Lumina Probiotic: Lumina features probiotic supplements that often combine multiple bacterial strains. Their approach emphasizes synergy among strains for broader digestive support.
  • Omni-Biotic: Omni-Biotic specializes in different blends tailored to specific needs (e.g., stress support, immune health). Each formula highlights particular strains and their intended benefits.
  • Fairvital: Fairvital provides an assortment of health products, including probiotics that may be combined with vitamins, minerals, or other nutrients.
  • Puori: Puori is known for clean-label supplements. Their probiotics often pair with prebiotic fibers, potentially offering extra support for beneficial gut bacteria.

Because everyone’s microbiome is unique, these brands (or any other probiotic products) might work differently from person to person. Checking specific ingredient lists, CFU counts, and strain types is key.

Microbiome test kits: identify the right probiotics

Microbiome test kits offer a practical way to see what’s really happening in your gut’s microbial ecosystem, so you can take informed steps toward better health. Think of them as a snapshot of which microbes are hanging out, what they’re producing, and how those activities might be influencing everything from digestion to mood. Rather than labeling certain bacteria as outright “good” or “bad,” these tests measure how different strains behave in the environment you create—your diet, stress levels, and lifestyle choices all make a big difference.

By providing concrete data on potentially harmful or beneficial metabolites, test kits can reveal if an imbalance is at the root of issues like occasional bloating, sluggishness, or an overactive immune response. From there, a personalized plan (often including targeted foods or nutrients) can help restore harmony to your gut microbiome. Ultimately, these kits empower you to take a science-backed approach to feeling your best, recognizing that a healthy gut isn’t just about which microbes you host—it’s about guiding them to work with, not against, your body.

Where to Buy: A Brief Overview of Microbiome Test Kits

If you’re looking to dive deeper into your gut’s microbial activities, you’ll find several at-home test kit providers that can help. Each of the following brands offers its own approach to analyzing your microbiome, often pairing detailed data with personalized recommendations. Keep in mind that results can vary from person to person, and it’s wise to consult a healthcare professional when interpreting findings. Here are a few places to start:

  • Macromo: Focuses on advanced data analytics to break down your microbiome’s individual components.
  • Viome: Provides customized insights, with an emphasis on understanding microbial metabolites and potential dietary adjustments.
  • Getstride: Offers gut health testing kits aimed at daily nutrition and lifestyle optimization.
  • Biocrates: Specializes in metabolic and microbiome analysis for a clearer picture of how your gut impacts overall health.
  • Iollo: Focuses on gut intelligence and personalized protocols to help you manage potential imbalances. 

Practical tips: making probiotics part of your day

Curious about giving probiotics a try? Below are some action-oriented considerations to guide you. Think of them as a friendly set of suggestions rather than hard rules:

  1. Speak with a professional: If you’re dealing with serious health conditions or are on medication, definitely ask your doctor, pharmacist, or dietitian about whether probiotics are right for you. You might need a specific strain for your situation—or maybe they’ll help you realize that a high-quality yogurt is enough.
  2. Opt for research-backed strains: Bifidobacterium longum and certain Lactobacillus strains have been studied for anti-inflammatory and immune-boosting benefits. Does the product provide detailed information about the specific strain(s)?
  3. Check CFU counts and quality: Higher colony-forming units (at least 1 billion) can be more effective for maintaining a robust gut microbe population. Ideally, you’d look for third-party certifications that confirm the product’s potency and purity.
  4. Mix up your sources: Supplements can be convenient, but fermented foods—think yogurt, kefir, kimchi, sauerkraut—bring additional nutrients, plus variety for your gut. Combining both a supplement and fermented foods is sort of a “belt and suspenders” approach.
  5. Follow the label directions: Different probiotics absorb better at different times of day, some with food, some without. Check the label. Also, consistency is key—don’t expect a single capsule or a spoonful of kimchi to transform your health overnight.
  6. Track your body’s response: Pay attention to changes in digestion, mood, energy, skin condition—any shift could provide clues about how well your chosen probiotic is working for you.

Beyond probiotics: the importance of a balanced lifestyle

Probiotics might play a crucial role in the puzzle of aging well, but they’re hardly the only piece. If you’re aiming for longevity, think holistically. A balanced diet, including plenty of fiber-rich fruits and vegetables to feed those beneficial bacteria, is a must. Regular exercise helps keep inflammation at bay, which in turn supports your gut microbiota. Sleep is another hidden gem—disrupted sleep can negatively affect gut balance. And let’s not forget the social dimension: strong relationships and mental well-being can also influence your physical health, indirectly supporting a better immune system. In other words, it’s never just about popping a supplement.

Addressing the elephant in the room: are probiotics enough?

Here’s the big question: if some probiotics can help reduce inflammation, support immune function, and even keep your mood in check, then are they enough to extend your lifespan? It’s tempting to say “maybe,” but truthfully, the current research leaves us with more questions than concrete answers. Some studies hint at promising results—certain probiotic strains might indeed help mitigate aspects of aging. Yet other studies underscore a lack of definitive proof or point to the need for larger, more controlled trials.

Put differently, probiotics are like a supportive friend on your journey to better health, but they’re not some all-powerful wizard. The notion that a particular capsule or a bit of fermented food can erase decades of wear and tear, or singlehandedly transform the gut microbiome, is a stretch. The real power may be in consistent, small gains—lowering chronic inflammation here, slightly boosting immune function there—which, over time, could have a valuable cumulative effect.

Final thoughts: a balanced view about probiotics

So, do probiotics hold the secret to a long and vibrant life? Well, maybe kind of. They appear to be one helpful tool in a larger toolkit that might promote healthy aging—particularly if you choose reputable strains, maintain a balanced lifestyle, and keep expectations realistic. Yet it’s also true that the science has a long way to go. The complexities of the microbiome are staggering, and commercial hype often leaps far ahead of what we truly understand.

In the meantime, if you enjoy the taste of fermented foods or find that a certain probiotic helps keep your digestion in check, go for it! It could be a gentle nudge toward better gut health, which in turn might help you age more comfortably. Just stay clear-eyed: consult professionals when in doubt, don’t buy into claims that sound too good to be true, and, basically, keep your healthy skepticism right alongside your enthusiasm.

After all, longevity is not a destination but a journey. Probiotics might be your friendly sidekick along the way—and if you ask me, that’s pretty exciting, even if we don’t have all the answers yet. 


Published: March 12th, 2025

Author: Volker Blasek

Volker Blasek is a technical editor with a background in horticulture, fueled by a volunteer year on an organic farm. His passion for nature and conservation, paired with his expertise in psychology and science, shapes his engaging and thoroughly researched content. As a medical editor, he has authored over 3,000 articles on topics such as nutrition, diseases, symptoms, naturalopathy, and home remedies, delivering insightful and accessible reporting for a wide range of audiences.

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Vegan collagen supplements can provide these essential nutrients, helping individuals meet their dietary needs and potentially enhance their overall health.Top 5 Vegan Collagen SupplementsWith a variety of vegan collagen supplements on the market, we've evaluated and ranked the top five options based on scientific backing, effectiveness, and user reviews:1. Avea Collagen ActivatorHow It WorksAvea’s Collagen Activator stands out with its scientifically designed Colgevity™ blend. This unique formulation includes crucial amino acids (glycine, L-proline, L-hydroxyproline), potent antioxidants like Astaxanthin and Acerola Cherry Extract, and the innovative compound Calcium Alpha-Ketoglutarate (Ca-AKG).Avea Collagen ActivatorWhat Makes Avea Collagen Activator Stand OutDeveloped through rigorous research at ETH Zurich, Avea specifically targets the body's collagen production pathways at the cellular level. Its scientifically robust approach significantly enhances your body's natural collagen synthesis, resulting in noticeable improvements in skin elasticity, hydration, and joint health.Why It’s More Effective Than Traditional Collagen PowdersClinical evidence demonstrates that Avea’s Collagen Activator boosts collagen production up to four times more effectively than traditional collagen supplements. Its exceptional effectiveness arises from its scientifically optimized formulation, the inclusion of longevity-supportive Ca-AKG, and high bioavailability of nutrients.Avea is an ideal choice if you're seeking a scientifically proven, innovative, and vegan-friendly approach to maintaining youthful skin and overall wellness.2. Feel Pro CollagenFeel Pro Collagen features VeCollal®, an advanced vegan collagen booster known for its extremely high bioavailability. This means your body easily absorbs and utilizes its collagen-stimulating nutrients. The formula is designed for optimal results, promoting visibly improved skin hydration and firmness with regular use.3. Future Kind Collagen BoosterFuture Kind offers a well-formulated amino acid blend popular in the USA. Known for convenience and consistent results, it combines ingredients such as biotin, silica, grape seed extract, and amla berry to support your natural collagen synthesis effectively. Ideal for those looking for a reliable daily supplement.4. Beloma Pro CollagenBeloma Pro Collagen combines effective ingredients in an aesthetically pleasing format. Its solid vegan collagen formula includes vital nutrients and plant-based extracts designed to enhance natural collagen production, benefiting both skin health and overall appearance.5. Yes Vegan CollagenYes Vegan Collagen is an accessible, budget-friendly option for those new to vegan collagen supplements. While its formulation is less scientifically robust compared to other brands, it still provides basic collagen-building nutrients beneficial for maintaining healthy skin and joints.ConclusionWhile every vegan collagen supplement on this list offers something valuable, Avea Collagen Activator definitely stands out in our book due to its science-backed and genuinely innovative formula. Their unique Colgevity™ blend, developed at ETH Zurich, seems to offer superior effectiveness by directly enhancing your body's own collagen-making abilities. So, for those who are really serious about achieving that vibrant skin, those happy joints, and overall wellness through a sustainable and ethical approach, Avea Collagen Activator looks like the clear frontrunner.

Founder interview: Dr. Emil Kendziorra, Founder & CEO at Tomorrow Biostasis
Lifespan Extension Interventions

3 min read

Founder interview: Dr. Emil Kendziorra, Founder & CEO at Tomorrow Biostasis

In our Founder Interview series, we highlight the brightest minds in preventive health, wellness, and longevity. In Episode 6, we’re honored to feature Dr. Emil Kenziorra, founder and CEO at Tomorrow Biostasis—one of the world-leading human cryopreservation experts.Tell us a little about yourself and your current ventureDoctor and researcher by training, entrepreneur by trade. Longevity has always been my motivation, with a focus on maximal life span extension. I'm running Tomorrow.bio and the non-profit European Biostasis Foundation to push human cryopreservation forward.How do you balance the demands of running a business while maintaining your own health and longevity?I've always worked a lot and my natural stress level is pretty low, plus good sleep and working out regularly. So all good :) Do you have a personal health goal? What is it? Not die - indefinitely, until I change my mind :)Before launching Tomorrow Biostasis, can you walk us through the “aha” moment that inspired the creation of your service?I've been involved in the longevity space in same capacity since 2007. I took a deep dive again in 2019 and after selling my last company in 2020, I switch to cryopreservation. There just isn't any meaningful progress in the field, with the billions of spending and decades of research maximum life span has not been extended by even a day. What sets Tomorrow Bio apart in the health and wellness industry?Accepting that maximal life span extension is not likely if we look at progress so far. If someone wants to live longer than currently possible, cryopreservation will be a necessary stopgap measure.What is the most groundbreaking or unexpected finding in the field of longevity research that you’ve come across recently, and why do you find it so compelling?Nothing really. The next big milestone will be a clinical trial that shows extension of maximal life span.  In your opinion, which emerging longevity trend or product will have the most transformative impact on our health over the next five years, and why?Gym, sleep, healthy food - rest is noise for now.One thing you wish more people knew about health and longevity?It's the most important thing in the world.What is the biggest longevity myth you’d like to debunk?Any thing that is available right now is proven to extend maximal life span. If you could recommend only one supplement for a longer, healthier life, which would it be, and what makes it indispensable?Vitamin D, most people have deficiencies. How old can we potentially become at maximum?No limit in theory. At least I'm not aware of any. What resources (books, podcasts, mentors) have been most valuable in your entrepreneurial journey?https://waitbutwhy.com/If there’s one message or insight you’d like readers to take away from your journey, what would it be?Work in Longevity! Focus on impact instead of money.