Magazine | Longevity Escape Velocity – living long enough to live forever

Longevity Escape Velocity – living long enough to live forever

Lifespan Extension Interventions Aging Research Rejuvenation
Written by Adrian Cull 8 min read
Longevity Escape Velocity – living long enough to live forever

Can We Live Forever?

As a New Zapiens reader, you’re probably already interested in wellness, health, and longevity - making lifestyle choices to feel good today and hopefully live a longer, healthier life. But just how long could that be? Is it possible to live a radically longer life, maybe to live forever?

As the founder of the Live Forever Club, you may expect me to answer “yes!” with glee. However, my answer is a bit more nuanced than that – it’s “no, but you may be able to live long enough to live forever.”

Let’s break that down a bit. The initial “no” is because whatever you do today, whether you have the funds to monitor every biomarker and benefit from all of the latest therapies (like, say, Bryan Johnson) you’ll still be lucky to make it to 100, let alone break the record for maximum lifespan – currently held by Jeanne Calment who made it to 122 back in 1997. 

However, eventually, it is inevitable that science and technology will beat nature at her own game. We’re barely a few centuries on from discovering the human cell and only understood how DNA was structured 70 years ago. Sequencing the first human genome was completed in 2003, having taken 13 years and almost three billion dollars – but now it can be done in under a day for a few hundred dollars. This, along with automated laboratories examining thousands of molecules at a time, means that our understanding of human biology, including ageing, is increasing exponentially. It is hard to imagine the depth of our knowledge in another 70 years, let alone 700 or 7,000 – so it’s not a matter of if, but when we will cure ageing.

Between the “no” and the “yes” comes the question, “can you live long enough to live forever?”. 

You can’t live forever today.

We might not cure aging within your current remaining life expectancy.

But that doesn’t mean you won’t live forever, as long as you reach longevity escape velocity.

The Science Behind Longevity Escape Velocity

Hold on. What is longevity escape velocity (LEV)? This is the idea that to live indefinitely, your life expectancy needs to increase a year for every year that you live, with your anticipated death constantly being kicked further down the road. Roughly speaking, in the 20th century, life expectancy increased about 3 months for every year that you lived, so we’re a quarter of the way there already.

Let’s use a concrete example, me, to see what that means in practice. I’m in my mid-50s so I have a remaining life expectancy of about 30 years. I don’t think that ageing will be fully under control by the time I’m in my eighties but that doesn’t write off my chances of living forever. Why? Because therapies that slow, and even reverse, ageing will start arriving during those 30 years which will buy me more time for improved therapies to be developed, which buys me more time again, and on, and on, and on.

“Really?” I hear you ask. I understand, you may not have heard anything about the prospect of radical life extension except for some crazy billionaires and over-hyped podcasters.

But things are moving rapidly on the science and investment fronts, and that will only speed up as early positive results encourage the industry further. For example, the XPRIZE Foundation (which launched its first prize in 1996 to launch the private space industry) recently announced a $101 million healthspan prize to be awarded to any organization able to reverse biological age by 10 years. To win, a team has to take a group of 50- to 80-year-olds, treat them for a year, and make their muscle, cognitive, and immune functions act as if they were 10 years younger. This isn’t targeting a specific disease, but the underlying causes of ageing. Over 600 teams, including universities and biotech companies, have entered the competition, and 40 were recently selected to receive $250,000 each to help fund their efforts – so there are a lot of intelligent people out there who really think that this is possible. 

And it is important that the XPRIZE Healthspan is targeting ageing because ageing increases the risk of all diseases. You may remember the covid curve showing the rapidly increasing risk of death from coronavirus infection the older you were – but this is the same for most age-related diseases too. Since the beginning of medicine, we’ve tried to tackle one disease at a time – but even if we cured cancer life expectancy would only increase by 2-3 years, because another age-related disease will pop up and kill you soon after that any way.

Ageing as the Root of All Disease

The better approach to allow us all to live longer, healthier lives is to repair the underlying damage caused by ageing. The drivers of ageing have been summarised in a highly cited research paper called the hallmarks of ageing. It described about a dozen biological processes that change with age – for example, shortening telomeres, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion. It’s not necessary to understand what each of the hallmarks of ageing are, rather to know that there are plenty of scientists and companies developing treatments for each of them which will slowly allow us to stop ageing.

Going back to my chances of living forever, how do initiatives such XPRIZE Healthspan impact that? Well, let’s be a bit pessimistic for now, and assume nobody wins this time around, and it takes until 2035 (instead of 2030) to reverse aging by 5 years (instead of 10-20 years hoped by the organisers). So, in 2035, I’m now 65 and should have a remaining life expectancy of 20 years – but the XPRIZE winners have just bought me another 5 years by reversing my biological age by half a decade – meaning my remaining life expectancy is 25 years.

Maybe the initial therapies were the low hanging fruit of rejuvenation therapies, so it takes another 10 years to reverse my biological age by another 5 years. Now, in 2045, I’m chronologically 75 years old, but biologically 65 – with a remaining life expectancy of 20 years (rather than a mere 10 if nothing had changed).

With medical research closely bound to data and computing, it is following a Moore’s Law style exponential increase in productivity. By the mid-2040s, or perhaps even sooner if quantum computers have their day, many experiments will be carried out ‘in silico’ (using computer simulations and digital twins). So, it is very likely that in the following 10 years (2045-2055) the rate of progress will increase, and my life expectancy will increase by another 10 years – effectively stopping me ageing. And shortly afterwards, 10 years of age-reversal will take less than 10 years to develop, so I’ll start to be rejuvenated. By the end of this century, it may be possible to fully rejuvenate my body and brain to its peak health as if I was a 20-something again.

I’ll summarise all of that in a table…

Chronological vs. Biological Age (2025–2100)
So, back to the original question. Can you live forever? Yes – assuming science and technology continues its exponential growth and it isn’t thwarted by government regulation, or worse, the breakout of World War 3. Though, of course, that also depends on how old you are today as improvements would have to come thick and fast to save people in 80s and 90s.

How to Increase Your Chances

How can you make sure you live long enough to live forever? As usual, follow what your mother told you – good diet, exercise, sleep and relationships. Experiment with supplements (though study them carefully and use biomarkers to track their impact) and keep an eye out for evidence-backed early treatments (maybe red-light therapy is worth a try). Beyond that, one of the best things you can do is talk to others about the prospect of radical life extension.

Raising awareness of the potential to cure ageing will help kick people out of the death trance which assumes curing ageing is impossible (and generates crazy arguments like death gives life meaning) and encourage more investment into the longevity industry; if governments think their voters want to cure ageing then they’ll fund it more, and if investors think there is demand for true rejuvenation treatments then they’ll start putting in the billions of dollars that this is going to take. 

Could I be wrong? Of course. Maybe reversing ageing is not inevitable, or just not on the timescales to save people alive today. But unless you have your hopes pinned on cryonics (preserving your body when you die hoping you can be reanimated in future) then what have you got to lose? 100,000 die of old age EVERY DAY – don’t let yourself become one of them.

Published: July 4th, 2025 · Updated: July 4th, 2025

References

1. Oldest verified people of all time (including Jeanne Calment)
2. DNA Sequencing Costs - National Human Genome Research Institute
3. XPRIZE Healthspan - XPRIZE Foundation
4. A.I. can radically lengthen your lifespan, says futurist Ray Kurzweil – Fortune magazine
Adrian Cull

Author: Adrian Cull

Founder of the Live Forever Club - promoting equality in longevity and raising awareness of radical life extension - https://liveforever.club

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When the Doctor Becomes the Patient — A personal story about circulating tumor cells, radical cancer screening and learning to live with uncertainty.
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13 min read

When the Doctor Becomes the Patient — A personal story about circulating tumor cells, radical cancer screening and learning to live with uncertainty.

I’m about to do something I’ve never done in writing before. Share something deeply personal.What you are about to read is my experience with aggressive cancer screening. My rational strategies. My emotional roller coaster ride. My story. But first a bit of background.Hi there.You might not know me yet. My name is Johan Hedevåg. I’m a longevity physician and health tech entrepreneur based in Stockholm, where I run Revi Health. Our clinic focuses on stemcells, metabolic & hormonal health and the art of longevity. Why is this relevant?You’re about to find out.Just another day?This story starts on a normal day in April. Ever-changing weather, not unlike most other April days. Little did I know, it would be the beginning of a very special journey. One of hope and despair. Of beauty and cancer.I was evaluating different offerings to include in our ultra high end health check.I had already settled on:Extensive blood workDexa scanFull-body MRIPerformance tests including grip strength and VO²maxUltrasound of all jointsColonoscopyCT-angiogramFull physical with doctorNext on the list of things to evaluate? Liquid biopsy.For those unfamiliar, let’s take a quick detour.What are liquid biopsies?A liquid biopsy is a simple blood draw, aiming to detect signs of early stage cancer.These tests don’t diagnose cancer. But they may detect signs that warrant further investigation — sometimes years before a tumor becomes visible.There are a few technologies available in this space. The main ones look for:Circulating Tumor Cells, CTC.Most tissue release cells into the blood stream, called circulating cells.This technology identifies circulating cells that resist apoptosis — our body’s way of clearing abnormal cells. That resistance is a red flag. These are very likely circulating tumor cells.Next, it dyes the cell surface and looks for specific markers (e.g. EpCAM, PanCK or CD45-) to identify the type of cell and its origin. Is it perhaps an epithelial cell or a mesenchymal cell?Circulating Tumor DNA, ctDNA.Stressed or dying cells release DNA into the blood stream. This is called cell free DNA, cfDNA.This technology detects cfDNA with mutated genes, known to be associated with cancer tumours. These snippets of DNA are called ctDNA.If DNA with a specific mutation is found, its origin can then be determined based on a large database of known mutations. Does it come from the Lungs or from the Pancreas?Moral of the quick detour? Neither technology is perfect but both are very promising.Back to the story.I had decided to evaluate one CTC test, called Trucheck, and one combined CTC and ctDNA test called Trublood. Both tests provided by Datar Cancer Genetics.A patient of mine, who had previously undergone Prostate cancer, asked me to take the Trublood test to see if ctDNA was present (can indicate a higher risk of cancer recurrence). I said yes.The Trucheck test, I took on myself.The process was smooth, both tests were sent to the UK for analysis and I went on to focus on other things.A couple of weeks passed by.A mixed bag of unpleasant feelings. May 12th, 9.53 pm.I was sitting in my living room couch, finishing up some work. I was tired. Bed time was imminent. Just one more email to go through…“Ah, from Datar Cancer Genetics, great.”I clicked on the attached PDF with my name on it, unlocked with the encryption key and started reading. Something caught my eye right away.☑ Circulating Tumor Cells (CTCs) detected, indicating higher risk of presence of cancer.“Wait a minute. That can’t be right.”My head started spinning. It was my first time reading a report like this, was I missing something. I continued to read.☑ Probability of Carcinoma.☑ Organ of origin could not be determined.“What the hell is going on? Clearly this must be a mistake.”My rational mind kicked in. Deep breath. Double and triple check!“Okay. It does say CTCs detected. What’s the plan?”Is it possible that the results got mixed up somehow?Can it be a false positive?Another deep breath. Let’s think this through.“My blood was shipped in the same cooling box as my patient’s. Room for error! Although, I did attach the labels on the test tubes myself and I’m 100% sure I didn’t mess that up. Still, I need to speak to the lab about it.”Keep breathing. Keep thinking.“Trucheck covers 80% of all solid tumours with a specificity of 96-99%. What hides in the missing percentages? What about the specificity for cells with the same markers as mine?”Immunocytochemistry AnalysisI turned to my personally trained chatGPT sparring partner.I'm analysing the results of a liquid biopsy. What's EpCAM and PanCK?Long answer. I focused. Keep reading. Keep processing.“They are surface proteins of epithelial cells. Got it. Remember to breathe.”Does this specific staining impact the overall specificity in any direction?Short answer.“If anything, it means that the specificity is higher.”I stopped breathing.🧠 Realisation 1: It’s very, very likely that I have a cancer tumour.I started breathing again. It was time to become a rational agent.“What’s the plan Johan? What’s the plan?”This is the plan.I held my breath for most of the time when coming up with it.Phase 1: Understand possible tumour origins.Phase 2: Set up a diagnostic protocol.Phase 3: Identify and implement strategies to:Do things that surpress tumour growthAvoid things that promote tumour growthDo things that promote general healthAvoid things harmful to general healthPhase 1: Possible tumour origins.I continued my chatGPT dialogue.If these markers are positive, what are the likely origins of the tumor?A structured answer.Tumor origins by markersGreat, thank you.I then went through my cancer heredity.Father: Malignant melanoma in his 60s. Survived.Mother: No known cancer.Grandfather on father's side: Prostate cancer at the time of death in his early 70s.Grandmother on father's side: Died of Pancreas cancer in her 50s.Uncle on father's side: No known cancer.Grandfather on mother's side: Died of lung cancer in his late 60s.Grandmother on mother's side: Breast cancer in her 60s. Survived.Uncle on mother's side: Colon cancer in his early 60s. Survived.That’s my entire blood related family (excluding my 2 children and my 4 cousins)“Not a pretty list.”🧠 Realisation 2: Most of the plausible cancer types run in my family.“That doesn’t matter. I’m a rational agent. Move on to the next phase 2.”Phase 2: The diagnostic protocol.I listened to myself and got to work.First step of a diagnostic protocol: Understand probability of origin.Second step: Cross run probability of origin with probability of death.Third step: Stack rank selected diagnostic procedures.Fourth step: Execute.I created a first version of a weighted probability estimate of different cancer types. It was based on population prevalence, heredity and personal characteristics (age, gender, lifestyle, medical history etc.).As before, I had the support of my beloved AI companion.Personalized cancer risk estimatesStep 1 was done. Drafts of step 2 and 3 started to take shape. I was not aiming for perfect. Plenty of room to iterate along the way.“I can do this. In fact, I’m in a unique position to do this. One of very few who can act on this information.”Time to take action.But first sleep.I went to bed. It was late and my brain was fried. Didn’t think I would be able to sleep but I passed out within minutes.Next morning.“I slept better than expected. Good. Now execute.”☑️ Action 1: Set up a call with the medical director of Datar Cancer Genetics.☑️ Action 2: Send referral for extensive blood work.☑️ Action 3: Book a dermatology exam.☑️ Action 4: Schedule a colonoscopy.☑️ Action 5: Send referrals for: Full-body MRI, Prostate MRI, Pancreas MRCP, CT Thorax, Testicular ultrasound.All done before lunch. Now what?“Do I just go on with life as normal? What about telling people? My wife? My parents? Surely I can’t tell my kids at this stage?”Wait! Had forgotten about phase 3 of the plan? It was time to implement survival strategies.I pushed away the difficult thoughts of communication and moved on.Phase 3: Strategies to surpress tumour growth and optimise general health.I was already living a very health life but it was time to optimise. I went high and low. Grasping for any straw with a limited downside and at least a theoretical upside.StrategiesDown regulate tumor growth (↓ proliferation, ↓ angiogenesis, ↓ mTOR, ↓ IGF-1)Starve tumor-supporting inputs (↓ glucose, ↓ growth factors, ↓ inflammation)Enhance immune function (↑ innate & adaptive response, ↑ NK cells, ↑ T cells)Boost systemic resilience (↑ mitochondria, ↓ inflammation, ↑ detox)TacticsDietTime-restricted eating (↓ insulin, ↓ IGF-1)3 days of water fasting (↑ autophagy)Low-glycemic diet (↓ glucose, ↓ insulin/IGF-1)<100g carbs/day (starves glycolytic tumors)1.5 - 2g protein (eggs, soybeans, chicken, whey, collagen, lentils) / kg / day.No alcohol (ethanol is carcinogenic and immunosuppressive)Avoid processed meat, charred foods, excess dairy (↓ IGF-1, ↓ inflammation)Broccoli sprouts, kale, arugula, cauliflower, cabbage (↑ detox)Garlic, onions, leeks, shallots (↓ inflammation, ↓ angiogenesis, immune-modulating)Polyphenol-rich berries & fruits (DNA-protective, ↓ oxidation, ↓ angiogenesisFermented foods like kombucha & kimchi (↑ gut-immune axis)Pomegranate (↓ tumor growth and angiogenesis, ↑ apoptosis in cancer cells in vitro)Ginger (↓ inflammation)Exercise & RecoveryZone 2 + VO²max intervals (↑ NK cells, ↑ T-cells)Resistance training (↑ metabolic health, ↓ inflammation)Sleep optimisation (↑ T-cells, cytokine balance)Sauna (heat shock proteins, ↑ detox, immune modulation)Cold exposure (mitochondrial biogenesis, immune priming)SupplementsOmega-3 (↓ pro-inflammatory omega-6, ↓ COX-2)Green tea extract (↓ VEGF, ↓ mTOR)Curcumin (↓ proliferation)Vitamin D3 (↑ immune regulation)Zinc (↑ T-cells)Magnesium glycinate (↓ inflammation, ↑ sleep, mitochondrial support)Creatine monohydrate (↑ muscle mass, ↑ cellular energy)Quercetin phytosome (senolytic, ↓ inflammation)Oral vitamin C (↓ oxidation)CoQ10 (↑ mitochondrial function)GlyNAC (↓ oxidation, redox balance, mitochondrial repairTaurine (↓ oxidation, ↑ mitochondrial function)Whey protein powder & collagen (support muscle mass)Psyllium husk (↑ gut-immune axis)1-MNA (↓ inflammation, endothelial protective effects)TMG (may normalise DNA methylation)PharmaceuticalsLow dose Aspirin (↓ COX-1/2, ↓ platelet aggregation,↓ metastasis)Low dose Mounjaro (↑ insulin sensitivity, ↓ inflammation)Colchicine (↓ inflammation, may reduce metastasis and tumor growth)Future candidatesIntravenous Vitamin C (pro-oxidant in tumor cells, generating hydrogen peroxide that selectively damages cancer cells)This might seem like a very extensive protocol. Thankfully I didn’t have to change basically anything regarding diet, exercise and recovery. Just adding some supplements and pharmaceuticals.24 hours had passed since I first read the results. My survival framework was done. It was time to think about communication.Balancing transparency and protection of others.“I don’t want to tell my wife yet. She’s already dealing with a lot, I don’t want her to have to live with the uncertainty. I’ll tell after the diagnostics are done. But, I need to tell someone or it might be too heavy of a burden.”So, I decided to call a friend. A good friend who happens to be both rational and compassionate. He’s also a fellow physician.Having someone to talk to was incredibly helpful and I’m very grateful for the unconditional support he gave me.Ticking one box after another.Things moved quickly from here.✅ I had a call with the medical director of Datar Cancer Genetics. He basically confirmed my fears. The probability of a test mix up was abysmal, as was the probability of a false positive.They had even run the test twice and gotten the same results. I have CTCs. Not tons of them but both tests clearly exceeded the threshold.There might still be a tiny, tiny possibility that these cells don’t come from a tumour but rather from some rare, undiagnosed inflammatory condition. Unlikely but not impossible.✅ My extensive blood work was basically normal. I did however have a S-CEA of 5. Right on the upper limit. This can be a sign of inflammation but it’s also a main marker used to track the progress of Colon cancer. Scary.✅ The dermatologist didn’t see anything suspicious and the testicular ultrasound was normal.With the new information at hand, I updated the probability matrix.Refined cancer probability matrixFunny how time just keeps moving.14 days had passed.It was time for my colonoscopy. I was probably the first patient they’ve ever had who was hoping that they would find a tumor.The 5 year survival for stage 1 Colon cancer is 91%. I’d take those odds.The colonoscopy was normal. No colon cancer.MRIs, MRCP and CT were scheduled 4 days later.Friday May 30th. One day before my father’s birthday.I spent 3 hours in the MRI and CT machines.The answer from the CT Thorax and Prostate MRI arrived that very same afternoon. No visible lung tumour. No signs of prostate cancer.Bladder and Esophagus cancer felt highly unlikely due to lack of heredity, risk factors and symptoms.Left on the list was pancreatic cancer.The 5 year survival for stage 1 Pancreatic cancer is 30-50%. I don’t like those odds.Friday evening and still no results.Pain and beauty might just be neighbours.The following weekend was emotional. My parents were visiting and we celebrated my dad’s birthday together.My thoughts were all over the place.“I don’t want pancreatic cancer. I want to see my kids grow up. I want to experience new things, generate new memories, learn new skills.”The next minute.“The world is so beautiful. I have lived an amazing life. More fortunate than most. As the wind is blowing in my hair, I wouldn’t want it any other way.”I don’t think anyone noticed.The reveal.Lunch time Monday June 2nd.I was standing by the computer in my home office. An email notification. The new test results had arrived. I once again stopped breathing.I logged into the referral system.“Breathe Johan. You gotta remember to breathe.”I clicked on the result from the full-body MRI and Pancreas MRCP.There are no suspicious findings for cancer or any other structural pathology.I could breathe again. Feelings of relief. The confusion.“So what's the verdict? What's the result? Do I have cancer or not?”The honest answer?I don't know.A false positive can’t be ruled out.The more likely explanation is that I have an extremely early tumour that may or may not materialise into active cancer.Living with uncertainty.Ironically, I have a lot more information now than prior to this situation. I know tons of things that I didn't know before.Yet, my brain tells me that my life is more uncertain.“I don’t know if I have cancer. I just know I have to live like I might. But wasn’t that always true?”Where to go from here?Well, the rational agent in me has created another screening protocol for the foreseeable future.Ongoing cancer screening planUntil that future reveals itself, I'm just gonna have to live in uncertainty.That’s as true for me as it is for you. As it is for everyone.As certainly as constant is the only change, uncertainty is the only certainty.

Founder Interview: Dr. Gil Blander, Founder of InsideTracker
Biomarkers
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9 min read

Founder Interview: Dr. Gil Blander, Founder of InsideTracker

In our Founder Interview series, we highlight the brightest minds in preventive health, wellness, and longevity. In Episode 7, we’re honored to feature Dr. Gil Blander, founder of InsideTracker—a leader in personalized health and longevity through biomarker-based insights.Tell us a little about yourself and your current ventureI am a scientist and entrepreneur with a lifelong passion for understanding the biology of aging and extending human healthspan. After earning my Ph.D. in biology from the Weizmann Institute of Science in Israel, I completed postdoctoral research on aging at MIT. My career has been dedicated to bridging the gap between scientific discovery and practical health solutions that people can use in their daily lives to optimize longevity, performance, and well-being.I founded InsideTracker with a team of scientists from MIT, Harvard, and Tufts with one clear mission: to help people live healthier, longer lives. InsideTracker is a personalized health platform that uses blood biomarkers, DNA, physiological data, food and supplement consumption, and daily habits to provide science-backed recommendations tailored to each individual. Our goal is to transform cutting-edge scientific research into actionable guidance that empowers people to make smarter, data-driven decisions about their nutrition, exercise, sleep, and overall lifestyle.As the host of the Longevity by Design podcast, I have the pleasure of speaking with the world’s leading researchers, clinicians, and thought leaders in the fields of aging, health, and performance. Each episode is an opportunity to explore the latest scientific breakthroughs and practical strategies for improving healthspan. My goal with this podcast is to make longevity science accessible, insightful, and actionable for anyone who wants to live a longer, healthier, and more vibrant life.How do you balance the demands of running a business while maintaining your own health and longevity?Balancing the demands of running a business with maintaining my own health and longevity is both a personal commitment and a daily practice. As a scientist and the founder of InsideTracker, I deeply believe that you can’t just talk about health, you have to live it. I make it a priority to regularly measure my own biomarkers, track my sleep using Oura ring, stay active, and follow personalized nutrition and lifestyle recommendations based on real data (the same approach we offer our customers). 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Progress, simplicity, and actionable clarity are the keys they value most.What is the most groundbreaking or unexpected finding in the field of longevity research that you’ve come across recently, and why do you find it so compelling?One of the most groundbreaking and exciting developments I’ve come across in longevity research recently is the concept of cellular reprogramming. The idea that we can potentially reset the biological age of cells, essentially turning back the clock without fully reverting them to a pluripotent, embryonic state, is truly remarkable. This process, sometimes called partial reprogramming, holds the promise of rejuvenating tissues and organs while preserving their identity and function.What makes this so compelling is that, unlike traditional approaches that try to slow aging or manage age-related diseases, reprogramming addresses the root causes of aging at the cellular level. It suggests that aging is not an irreversible decline, but rather a process that can be modified or even reversed under the right conditions. Early studies in animals have shown improvements in tissue function, resilience, and even lifespan extension, which could eventually translate to human health and longevity.If this technology can be safely and precisely controlled, it may fundamentally change how we think about aging, not as something inevitable, but as a modifiable biological program. The potential impact on healthspan and disease prevention is enormous, and that’s why I find this area of research so exciting.In your opinion, which emerging longevity trend or product will have the most transformative impact on our health over the next five years, and why?I believe personalized healthspan optimization—like what we do at InsideTracker—will have the most transformative impact, as it empowers individuals with tailored, data-driven insights to make meaningful, sustainable changes that improve both lifespan and quality of life.One thing you wish more people knew about health and longevity?Wish more people knew that health and longevity are driven 80% by behavior and only 20% by genetics, meaning your daily choices matter far more than your DNA.What is the biggest longevity myth you’d like to debunk?The biggest health and longevity myth I’d like to debunk is that there’s one “best” diet—like paleo—that works for everyone, or that your genetics significantly limit what you can achieve, and also the misconception that strength training is bad for women; in reality, personalized approaches and strength training are key to lasting health regardless of genetics.If you could recommend only one supplement for a longer, healthier life, which would it be, and what makes it indispensable?I’d recommend personalized supplementation based on your unique biomarkers, as targeting your specific nutritional needs is the most effective way to support a longer, healthier life.How old can we potentially become at maximum?Without cellular reprogramming, the maximum human lifespan appears to be around 120 to 122 years, as exemplified by the longest-lived person on record.If there’s one message or insight you’d like readers to take away from your journey, what would it be?Your health is your greatest investment — take control of it early, make decisions based on data and personalization, and small, consistent actions today will shape a longer, healthier, and more vibrant life tomorrow.

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5 min read

Breathwork isn’t just a wellness trend. It’s the language of your nervous system.

Most people think of breathwork as a way to calm down. A yoga add-on. Something gentle, a bit mystical, maybe even hard to take seriously.But what if I told you that breath isn’t just a relaxing tool? It’s how your nervous system speaks.I learned this the hard way. Years ago, when I was burned out and stuck in survival mode, someone told me to “just breathe.” I remember wanting to scream. Not because it was wrong, but because no one had ever explained how breath actually works. Or why it matters. Or what kind of breathing does what.Today, I teach women how to connect to their bodies and minds through movement, breath, and neurotraining. And the more I see it in practice, the more I know: your breath is not a soft skill. It’s a power tool.Let’s break it down.Your breath is a messageYour nervous system is always scanning your environment. It’s constantly asking: „Am I safe? Can I rest? Do I need to protect myself?“But it doesn’t get answers from your thoughts. It reads your posture, your muscle tension, and most importantly, your breath.Shallow, fast breathing tells your system there’s danger. Long, slow exhales tell it you’re safe. That’s not a metaphor. It’s neurobiology.Research from Stanford University shows that even a few minutes of deliberate, controlled breathing can reduce anxiety more effectively than mindfulness meditation. Why? Because it directly regulates the autonomic nervous system. You’re not trying to think yourself into calm. You’re breathing your body into it.Dr. Stephen Porges’ work on Polyvagal Theory supports this understanding. He shows how slow, rhythmic breath tones the vagus nerve, the main communicator between body and brain. Breath becomes a two-way signal. It is not just a symptom of how we feel but a way to change how we feel.And once you begin to understand this, you start realizing how often you’ve been holding your breath. Not just physically, but emotionally too.Different breaths, different resultsHere’s where most people get stuck. They try one style of breathwork, usually the classic deep belly breath, and expect it to fix everything.But not all breathing is the same. Different techniques do different things:Breath for energy: UpregulationThis one is great when you’re feeling frozen, sluggish, or mentally foggy. It’s the nervous system’s wake up button.Try short, sharp inhales through the nose and passive exhales like a soft sigh. Do 30 seconds and pause. Repeat if needed.This activates the sympathetic system in a healthy way. It energizes without overwhelming.Use it before a workout, a morning meeting, or when you’re stuck in a procrastination spiral.Breath for calm: DownregulationThis is what most people associate with breathwork. Long exhales, nasal breathing, and slowing the rhythm. It tells the body, “We’re safe now.”Try inhaling for 4 counts, exhaling for 6. Or even better, double the exhale length.You can also hum softly on the exhale. This vibration stimulates the vagus nerve and adds a grounding cue that the body reads as safety.It is ideal for anxious moments, bedtime, or emotional overwhelm.Breath for balance: Re-centeringSometimes we don’t want to energize or calm down. We want to return to our center.Try box breathing. Inhale for 4 counts, hold for 4, exhale for 4, hold again for 4. Repeat 3 to 5 rounds.This technique is used by elite performers under pressure, not because it’s fancy, but because it works.In your daily life, this is the perfect breath to use before a difficult conversation, while waiting for test results, or when you’re about to say yes to something you don’t really want.Breathwork isn’t escapism. It’s self-leadership.Here’s the thing. We’re not breathing to escape discomfort. We’re breathing to build capacity for it.One of my clients, a young woman juggling a demanding job and constant inner pressure to be perfect, once told me, “I feel like I’m always running, and my breath is chasing me.”Through consistent practice, she learned how to meet herself in that breathless moment. To pause. To exhale. To stay.That’s what breathwork gives us. The ability to stay. To respond instead of react. To feel without falling apart.And when you combine breath with movement, especially intuitive and non-linear movement, it becomes even more powerful. It becomes your return path to the body. To yourself.In my own sessions, I often begin strength or flow practices with just one minute of rhythmic breath. It’s a ritual. Not to prepare the body, but to invite it in.There’s a difference between pushing through a workout and inhabiting it.And that difference starts with your breath.One breath can change your stateYou don’t need a fancy studio. You don’t need a 60-minute session. You need one breath. One conscious inhale. One soft exhale.The next time you’re overwhelmed, frozen, spiraling in your head, stop.Feel your feet on the ground. Place a hand on your belly. Breathe in. Then breathe out a little longer.You are not behind. You are not broken. You are just one breath away from coming back to yourself.That is not some vague wellness trick. That is your body’s wisdom.That is how you lead yourself back.