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What do you think of ‘all-in-one’ dietary supplements for a long life? Are there any good products?

10 months ago (edited)

There are several combined supplements out there like the "Essentials Stack" from Bryan Johnson, "Life Extension Mix Capsules" or "Best Age Superior" from Biogena One. I'm just wondering if taking such "all in one supplements" can be recommended for beginners and are there good ones?


See...
https://blueprint.bryanjohnson.com/products/essentials-stack?variant=49888565854493
https://de.iherb.com/pr/life-extension-life-extension-mix-capsules-360-capsules/86458
https://biogena.com/de-de/produkte/best-age-superior_p_3937812
and many more for such all-in-one-products.

I would always recommend to fix the basics (without supplementing) first. Then test what's missing. Supplement only what's missing. Am I wrong?
@hadi-saleh @karol @simon @dennis-esser @fabian-praschl @sandra-hagen @heiko-bartlog

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· 10 months ago (edited)

I agree recommending to fix the basics (without supplementing) first. Then test what's missing (essential micronutrients). Supplement only what's missing.

But there might be some (non-essential longevity) supplements that might be beneficial even if you don't have a measurable deficit. E.g. Taurine, Creatine, Quercetin, Cholin, TMG, Fisetin, ...?

What do you think?

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· 10 months ago (edited)

@heiko-bartlog is already too deep in the rabbit hole, I cannot imagine how my friends or families would react if I recommend them taurine, fisetine or quercetine ("querce... what??"). 😜

I understand @brgmn 's question more like: what to recommend to people who don't want to spend much time on researching and optimizing their whole body, but might want to look for some basic support?

To be honest, I do recommend multis for that case, at least for people who say "one pill per day is the maximum effort I am willing to take!". 🤷🏼‍♀️

In that case I recommend edubily's Multi (https://edubily.de/products/das-multi) which contains most of the essential micronutrients but without overdosing on any of them.

I'd rather recommend a product that is a bit under-dosed like the Multi (hoping for some micronutrients from nutrition) than one with very high doses, which could be risky for some (e.g., people with genetic predispositions for example for for iron cumulation, or like with high-dose b vitamins which some people not tolerate well - and which honestly is simply not necessary in most cases).

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· 10 months ago (edited)

@sandra-hagen Thanks! You mean https://edubily.de/products/das-multi ? @heiko-bartlog I only take creatine from your list. What am I missing? 🤔

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· 10 months ago

If someone is completely in the health game, these drinks are probably superfluous. Unless you are in a stressful phase and have little time to take care of your supplements. These supplements are also super handy when travelling.

However, many people are not yet that familiar with the subject and never want to be. It's like a service consultation: I have no idea. Don't want to have a clue either. But there is someone who does. He recommends the best there is and I trust him.

That's how I see these all-in-one drinks.

There are also people who don't want to take tablets. These drinks are also very practical for them.

However, I would still recommend everyone to take a look at the ingredients. I find AG1 too intrasparent. I find Biogena One very transparent. That's why I recommend All in One Drinks, which are as transparent as possible about what you're taking.

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· 10 months ago

@sandra-hagen @brgmn 😎

With Quercetin and Fisetin I just wanted to name some examples of supplements that are not essential (so you cannot measure any deficit) but might have potential benefits for longevity. Other examples: Spermidine, AKG, EGCG, and of course: Resveratol ;)

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· 10 months ago (edited)

@heiko-bartlog testing and then supplementing is what I recommend (I'm a longevity physician). But for beginners who haven't tested, a moderate dose of omega-3x (~1g EPA/DHA), vitamin D3/k2 (~2000IU/100mcg), creatine (~5g), and perhaps magnesium is reasonable and significantly helpful for most.

I generally do not recommend general multivitamins - it's often the first thing I have to peel off when I do testing. Folks end up high on certain results (selenium is common), low on others (copper because the zinc has been elevated), and there are also many ingredients that have highly variable effects, some adverse for certain individuals (berberine, b6 just to name a couple).

Not to mention there is questionable evidence for many of the ingredients (see Taurine's recent evidence in 2025). At the doses included, hopefully they're at least not harmful but the fewer excess ingredients the easier it is to tell what might be beneficial vs harmful.

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· 10 months ago

@hillary-lin interesting, what did I miss regarding Taurine? There was one study saying that it does not seem to deplete with age, but I didn't read anything that declines the benefits.

Selenium is a perfect example for "one size DOES NOT fit all" as in germany most people have a deficit, I think it's the opposite in the US, isn't it?

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· 9 months ago (edited)

I'd say there are good for a baseline, and assuming you can afford it, as i believe you won't overdose or get adverse effects easily. I take Sunday All in One Premium and next to it another 12-15 supplements, some of which are already in it, but i want a higher dose. I'd say the all-in-ones are also practical when travelling.

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