Longevity Knowledge BETA
Biohacking
Table of Contents
What Is Biohacking?
Biohacking is the practice of systematically modifying your biology through informed self-experimentation, technology, and environmental design. It sits at the intersection of science, technology, and personal wellness — drawing from fields as diverse as molecular biology, nutritional biochemistry, chronobiology, and neuroscience. At its core, biohacking treats the human body as a complex system that can be measured, understood, and optimized through iterative testing and data-driven adjustments.
The Quantified Self
The foundation of effective biohacking is measurement. The quantified self movement emphasizes continuous tracking of biological variables to establish baselines and measure the impact of interventions. Wearable devices capture heart rate variability (HRV), sleep stages, blood oxygen saturation, skin temperature trends, and activity patterns. Continuous glucose monitors (CGMs) reveal individualized glycemic responses to specific foods, enabling personalized nutrition strategies that stabilize blood sugar — a key factor in metabolic health and longevity. Regular blood panels tracking biomarkers like fasting insulin, hs-CRP, ApoB, and hormone levels complete the picture, providing objective data where subjective perception often fails.
Environmental and Lifestyle Optimization
Biohacking extends beyond supplementation and testing into deliberate environmental design. Light environment management — morning sunlight exposure to entrain circadian rhythms, blue-light blocking glasses in the evening — profoundly influences sleep quality, cortisol patterns, and melatonin production. Temperature manipulation through cold exposure (cold plunges, cryotherapy) and heat exposure (sauna protocols) triggers hormetic stress responses that improve cardiovascular fitness, immune function, and metabolic rate. Air quality optimization with HEPA filtration and CO2 monitoring can significantly improve cognitive performance and sleep quality.
Nootropics and Cognitive Enhancement
Cognitive optimization is a major branch of biohacking. Evidence-based nootropics include creatine monohydrate (shown to improve working memory and reasoning), lion's mane mushroom (stimulates nerve growth factor), and L-theanine paired with caffeine (improves focused attention without jitteriness). More advanced biohackers explore racetams, modafinil, or microdosing protocols, though these carry higher risk profiles and regulatory considerations.
Principles for Safe Self-Experimentation
- Change one variable at a time to establish clear cause-and-effect relationships
- Establish a baseline measurement period of at least two weeks before introducing any intervention
- Track both objective data (blood markers, HRV, sleep scores) and subjective metrics (energy, mood, cognitive clarity)
- Apply the precautionary principle — favor well-studied interventions with established safety profiles before exploring experimental approaches
- Maintain a detailed biohacking journal documenting interventions, dosages, timing, and outcomes
Track before optimizing
What is biohacking?
Is biohacking safe?
What are the best biohacking tools for beginners?
How is biohacking different for women?
What does a biohacking morning routine look like?
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