Men's health: hormonal optimization and longevity

Men's health encompasses a spectrum of physiological and psychological factors unique to male biology, including hormone regulation, reproductive health, cardiovascular function, and cancer prevention. Testosterone, the primary male hormone, regulates muscle mass, bone density, sexual function, mood, and metabolic health. From approximately age 30, testosterone naturally declines 1% annually, though rates vary significantly among individuals [1]. This age-related decline, distinct from pathological hypogonadism, influences body composition, strength, libido, and overall vitality.

Testosterone and male vitality

Testosterone influences virtually every aspect of male health. Optimal levels support lean muscle mass, reduced body fat, cognitive function, mood stability, cardiovascular health, and bone density. Low testosterone correlates with increased risk of metabolic syndrome, type 2 diabetes, cardiovascular disease, depression, and cognitive decline. Symptoms include reduced libido, erectile dysfunction, fatigue, loss of muscle mass, increased body fat, decreased motivation, and poor concentration.

Prostate health and cancer prevention

The prostate, a walnut-sized gland surrounding the urethra, produces seminal fluid and is subject to three primary conditions: benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer. BPH involves enlarged prostate tissue, commonly occurring with age. Prostate cancer represents the second-most common cancer in men, with risk increasing after age 50 [2]. Protective factors include consumption of lycopene (from tomatoes), selenium, zinc, and polyphenols from plant foods.

Essential screenings for men

Men should undergo regular health screenings tailored to age and risk factors. Blood pressure checks should occur at least annually. Lipid panels help assess cardiovascular risk. Diabetes screening through fasting glucose or HbA1c is recommended. Prostate screening discussions should begin at age 50 for average-risk men, or age 45 for those with family history. Colonoscopy for colorectal cancer screening begins at age 45.

Exercise and hormonal health

Resistance training provides one of the most effective natural methods for supporting healthy testosterone levels. Research demonstrates that compound exercises like squats and deadlifts performed with heavy weights significantly increase acute testosterone production [3]. This hormonal response supports muscle protein synthesis and metabolic health over time.

Sleep and hormone production

Quality sleep is essential for optimal testosterone production. The majority of daily testosterone release occurs during deep sleep phases. Studies show that even one week of sleep restriction to 5 hours nightly reduces testosterone by 10-15% while increasing cortisol levels [4]. Prioritizing 7-9 hours of uninterrupted sleep supports healthy hormonal balance and recovery.

1.

Lift Heavy to Boost Testosterone

Compound lifts like squats, deadlifts, and bench presses performed with heavy weights (80-90% of 1-rep max) and adequate rest periods trigger significant testosterone release. Train major muscle groups 2-3 times weekly.
pubmed.ncbi.nlm.nih.gov
2.

Sleep 7-9 Hours for Hormone Production

Most testosterone is produced during deep sleep phases. Research shows just one week of sleep restriction to 5 hours nightly reduces testosterone by 10-15% and increases cortisol.
3.

Eat Tomatoes for Prostate Protection

Lycopene from cooked tomatoes shows strong evidence for prostate cancer prevention. Include tomato sauce, paste, and cooked tomatoes in your diet several times weekly.
4.

Get Screened Starting at Age 45

Men should begin prostate cancer screening discussions at 45 if African American or with family history, and 50 for average risk. Colorectal screening begins at 45 for all men.
5.

Manage Stress for Hormonal Balance

Chronic stress elevates cortisol which suppresses testosterone production. Practice daily stress reduction through meditation, time in nature, or physical activity.
1.

What are normal testosterone levels for men?

Normal total testosterone ranges from 300-1000 ng/dL, though optimal levels for vitality often fall in the 400-700 ng/dL range. Levels naturally decline about 1% per year after age 30. Testing should be done in the morning when testosterone peaks, and include free testosterone and SHBG for complete assessment.
2.

Can lifestyle changes naturally boost testosterone?

Yes. Resistance training, especially compound exercises with heavy weights, significantly increases testosterone. Adequate sleep (7-9 hours), maintaining healthy body fat levels (10-20%), managing stress, and consuming sufficient zinc and vitamin D all support healthy testosterone production without medication.
3.

What other screenings should men prioritize?

Beyond prostate screening, men need regular blood pressure checks, lipid panels for cardiovascular risk, diabetes screening (HbA1c), colorectal cancer screening starting at 45, and skin exams for melanoma. Mental health screening is equally important given higher male suicide rates.
4.

At what age should men start prostate cancer screening?

Current guidelines recommend men with average risk begin prostate screening discussions at age 50. Men at higher risk—African American men or those with a first-degree relative with prostate cancer—should begin at age 45. Screening involves PSA blood tests and possibly digital rectal exams, with frequency depending on baseline results.

No discussions yet

Be the first to start a discussion about Men's Health.

This content was created and reviewed by the New Zapiens Editorial Team in accordance with our editorial guidelines.
Last updated: February 26, 2026

Discover trusted longevity brands
and expert health stacks

Stop wasting money on ineffective products
Save up to 5 hours of research per week
Delivered to your inbox every Thursday